Cost-effectiveness analysis of lenvatinib treatment for patients with unresectable hepatocellular carcinoma (uHCC) compared with sorafenib in Japan

Journal of Gastroenterology
Masahiro KobayashiShunya Ikeda

Abstract

Lenvatinib demonstrated a treatment effect on overall survival by the statistical confirmation of non-inferiority to sorafenib for the first-line treatment of uHCC. The objective of this study was to evaluate the cost-effectiveness of lenvatinib compared with sorafenib for patients with uHCC in Japan. A partitioned-survival model was developed to estimate the cost-effectiveness of lenvatinib versus sorafenib when treating uHCC patients over a lifetime horizon and considering total public healthcare expenditure. Efficacy and safety data were extracted from the REFLECT trial. Utility values were derived from the European Quality-of-Life 5-Dimension Questionnaire, conducted with patients enrolled in the REFLECT trial. Direct medical costs, such as primary drug therapy, outpatient visits, diagnostic tests, hospitalization, post-progression therapy, and adverse-event treatments, were included. Cost parameters unavailable in the clinical trial or publications were obtained based on the consolidated clinical standards from a Delphi panel of four Japanese medical experts. For lenvatinib versus sorafenib, the incremental cost was - 406,307 Japanese Yen (JPY), and the incremental life years and quality-adjusted life years (QALYs) were 0....Continue Reading

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Citations

May 19, 2020·Journal of Comparative Effectiveness Research·Hongfu CaiMaobai Liu
Sep 24, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Weiting LiaoQiu Li
Nov 21, 2019·Alimentary Pharmacology & Therapeutics·Saroja BangaruAmit G Singal
Apr 21, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi TerashimaShuichi Kaneko
Apr 18, 2019·Drugs·Zaina T Al-SalamaLesley J Scott
Aug 13, 2020·Signal Transduction and Targeted Therapy·Ao HuangJian Zhou
Jul 1, 2020·Current Gene Therapy·Chen-Hao ZhangQiang Gao
Feb 7, 2020·Journal of Clinical and Experimental Hepatology·Ashish KumarUNKNOWN INASL Task-Force on Hepatocellular Carcinoma
Nov 17, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John D GordanMichal G Rose
Jul 22, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi TerashimaShuichi Kaneko
Aug 25, 2021·PharmacoEconomics Open·Sydney C YuenT Joseph Mattingly
Nov 10, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yuji TohdaIchiro Arakawa

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Methods Mentioned

BETA
surgical resection

Software Mentioned

Excel
REFLECT

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