Cost-effectiveness analysis of liquid-based cytology and human papillomavirus testing in cervical cancer screening

Obstetrics and Gynecology
Michael A BidusEvan R Myers

Abstract

To compare the outcomes of several cervix cancer screening strategies in a military population using a model that considers both direct and indirect costs of health care. A Markov model of the natural history of cervical cancer was used to simulate an age-stratified cohort of 100,000 active duty women in the U.S. Army. Total costs and incremental cost-effectiveness ratios were estimated for different modalities of screening: liquid-based cytology with testing for human papillomavirus (HPV) irrespective of cytologic results compared with liquid-based cytology with HPV detection for cytologic results of atypical cells of undetermined significance (reflex HPV). The costs and outcomes of these screening methods were evaluated separately as well as in combination (liquid-based cytology and reflex HPV before age 30 years and DNA and Pap test every 3 years thereafter). Each of these screening methods was evaluated at 1-, 2-, and 3-year intervals. A screening strategy of liquid-based cytology and reflex HPV every 2 or 3 years is the least costly strategy among active duty women irrespective of age, especially when accounting for time costs associated with screening, diagnosis, and treatment of cervix cancer. A strategy of liquid-based ...Continue Reading

References

Mar 11, 1998·The Journal of Arthroplasty·M D Ries
May 2, 2001·International Journal of Technology Assessment in Health Care·T I ShiremanS J Goldie
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Thomas C WrightUNKNOWN ASCCP-Sponsored Consensus Conference
May 4, 2002·JAMA : the Journal of the American Medical Association·Jane J KimSue J Goldie
Feb 7, 2003·The New England Journal of Medicine·Thomas C Wright, Mark Schiffman
Jun 17, 2003·Journal of the National Cancer Institute. Monographs·Eduardo L Franco
Aug 14, 2003·JAMA : the Journal of the American Medical Association·Shalini L Kulasingam, Evan R Myers
Nov 25, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN American College of Obstetricians and Gynecologists
Sep 11, 2004·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Sarah Dewilde, Rob Anderson
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Robert A SmithHarmon J Eyre
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani

❮ Previous
Next ❯

Citations

Mar 4, 2008·Journal of the National Cancer Institute·Jeremy D Goldhaber-FiebertSue J Goldie
Oct 6, 2007·Journal of Lower Genital Tract Disease·Neal M LonkyBradley J Monk
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ralph P InsingaMargaret M Madeleine
Oct 31, 2007·Population Health Metrics·Jeremy D Goldhaber-FiebertJoshua A Salomon
Dec 7, 2007·Mayo Clinic Proceedings·Harry J LongBobbie S Gostout
Apr 13, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SroczynskiU Siebert
Dec 22, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·James F O'MahonyInge M C M de Kok
Jan 30, 2010·International Journal of Cancer. Journal International Du Cancer·Johannes BerkhofChris J Meijer
Jun 18, 2011·Journal of Evaluation in Clinical Practice·Meng-Kan ChenHsiu-Hsi Chen
Mar 27, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maaike G DijkstraChris J L M Meijer
Sep 17, 2016·Health Technology Assessment : HTA·Henry C KitchenerChris Roberts
Aug 8, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M O L P CostaM T S Correia
Aug 29, 2007·International Journal of Cancer. Journal International Du Cancer·Paolo Giorgi-RossiUNKNOWN NTCC Working Group
May 3, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shao-Kai ZhangYou-Lin Qiao
May 6, 2010·Archives of Pathology & Laboratory Medicine·R Marshall AustinMarek J Druzdzel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved