Cost-effectiveness analysis of simeprevir in combination with peginterferon and ribavirin for treatment-naïve chronic hepatitis C genotype 1 patients in Japan

Journal of Medical Economics
Hiroyo KuwabaraHiroshi Yatsuhashi

Abstract

Simeprevir (SMV), a protease inhibitor, recently became available for the treatment of chronic hepatitis C (HCV) genotype 1 patients in Japan. The introduction of triple therapy using SMV in combination with peginterferon and ribavirin (PR) significantly improves the cure rate. The aim was to assess the cost-effectiveness of SMV with PR (SMV/PR) compared to telaprevir with PR (TVR/PR), PR alone, or no treatment in treatment-naïve patients in Japan. A Markov model was developed to reflect the natural disease progression of HCV and to estimate the average life years and lifetime healthcare costs per patient. Sustained virologic response rates were obtained from a network meta-analysis including randomized clinical trials conducted in Japan. Patient baseline characteristics, HCV progression rates, mortality, medical resource utilization, and unit costs were obtained from Japanese sources. Outcomes were reported as incremental cost-effectiveness ratios as well as incremental cost and life years. Various sensitivity analyses were conducted to assess the uncertainty around model outcomes. SMV/PR was estimated to be a cost-effective treatment option as more life years were gained by 0.235 and 0.873 years at a reduced cost by ¥263,037 ...Continue Reading

References

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Citations

Jun 21, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jagpreet ChhatwalFasiha Kanwal
May 19, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X LiE W Chan
Jun 1, 2017·International Journal of Technology Assessment in Health Care·Jörg MahlichBruno Rossi
Jul 19, 2017·The Annals of Pharmacotherapy·T Joseph MattinglyC Daniel Mullins
Jan 4, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kota NagaiKoji Kawakami
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Jaume Puig-JunoyMíriam Solozabal

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