Cost-effectiveness analysis of two therapeutic schemes in the treatment of acromegaly: a retrospective study of 168 cases

Journal of Endocrinological Investigation
L DuanF Gu

Abstract

This study aimed to estimate the cost effectiveness of two therapeutic schemes, including preoperative medical therapy and surgery as primary therapy. A total of 168 acromegaly cases were retrospectively investigated for a comparative evaluation of surgery and preoperative medical therapy. A Markov model was developed to simulate treatment cost-effectiveness and progression of acromegaly. Overall effectiveness of preoperative medical therapy was significantly higher than surgery in acromegalic patients with macroadenoma. In addition, life expectancy, and cost per life-year gained were slightly higher in the preoperative medical therapy group than in the initial surgery group when patients received surgery as a secondary treatment. Interestingly, preoperative medical therapy achieved a significant increase in life expectancy and reduced cost for patients who received long-term medical therapy as secondary treatment. In acromegalic patients with macroadenoma, the cost-effectiveness analysis revealed more satisfactory outcomes in preoperative therapy, compared with primary surgery.

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Citations

Oct 22, 2016·Journal of Endocrinological Investigation·T ApaydinP Kadioglu
Aug 31, 2018·Pituitary·Letícia P LeonartRoberto Pontarolo
Aug 21, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Ewa OrlewskaKatarzyna Orlewska
May 6, 2019·Expert Review of Pharmacoeconomics & Outcomes Research·Carmen PeralCarlos Rubio-Terrés
Jul 30, 2021·Applied Health Economics and Health Policy·Jiehua ChengShangcheng Zhou
Oct 26, 2021·Frontiers in Endocrinology·Thierry BrueGérald Raverot

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