Cost-effectiveness analysis of universal maternal immunization with tetanus-diphtheria-acellular pertussis (Tdap) vaccine in Brazil

Vaccine
Ana Marli Christovam SartoriH M D Novaes

Abstract

Pertussis incidence has increased significantly in Brazil since 2011, despite high coverage of whole-cell pertussis containing vaccines in childhood. Infants <4 months are most affected. This study aimed to evaluate the cost-effectiveness of introducing universal maternal vaccination with tetanus-diphtheria-acellular pertussis vaccine (Tdap) into the National Immunization Program in Brazil. Economic evaluation using a decision tree model comparing two strategies: (1) universal vaccination with one dose of Tdap in the third trimester of pregnancy and (2) current practice (no pertussis maternal vaccination), from the perspective of the health system and society. An annual cohort of newborns representing the number of vaccinated pregnant women were followed for one year. Vaccine efficacy were based on literature review. Epidemiological, healthcare resource utilization and cost estimates were based on local data retrieved from Brazilian Health Information Systems. Costs of epidemiological investigation and treatment of contacts of cases were included in the analysis. No discount rate was applied to costs and benefits, as the temporal horizon was one year. Primary outcome was cost per life year saved (LYS). Univariate and best- and ...Continue Reading

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Citations

Nov 14, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louise B RussellAnushua Sinha
Jan 28, 2017·Human Vaccines & Immunotherapeutics·Ana Marli Christovam SartoriPatrícia Coelho de Soárez
Aug 18, 2018·Human Vaccines & Immunotherapeutics·Eder Gatti FernandesHillegonda Maria Dutilh Novaes
Jan 12, 2017·Journal of the Pediatric Infectious Diseases Society·Michelle M HughesJoanne Katz
Jul 19, 2019·Expert Review of Vaccines·Angela GentileElsa Sarti
Feb 9, 2017·Clinical and Experimental Vaccine Research·Hyo-Jin Lee, Jung-Hyun Choi
Mar 8, 2017·Clinical Case Reports·Motoharu OchiHirokazu Tsukahara
Mar 19, 2019·Journal of Immunology Research·Carolina Argondizo-CorreiaCyro Alves de Brito
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