Cost-effectiveness and health-related outcomes of screening for hepatitis C in Korean population

Liver International : Official Journal of the International Association for the Study of the Liver
Kyung-Ah KimSook-Hyang Jeong

Abstract

In the era of direct-acting antivirals (DAA), active screening for hidden hepatitis C virus (HCV) infection is important for HCV elimination. This study estimated the cost-effectiveness and health-related outcomes of HCV screening and DAA treatment of a targeted population in Korea, where anti-HCV prevalence was 0.6% in 2015. A Markov model simulating the natural history of HCV infection was used to examine the cost-effectiveness of two strategies: no screening vs screening and DAA treatment. Screening was performed by integration of the anti-HCV test into the National Health Examination Program. From a healthcare system's perspective, the cost-utility and the impact on HCV-related health events of one-time anti-HCV screening and DAA treatment in Korean population aged 40-65 years was analysed with a lifetime horizon. The HCV screening and DAA treatment strategy increased quality-adjusted life years (QALY) by 0.0015 at a cost of $11.27 resulting in an incremental cost-effectiveness ratio (ICER) of $7435 per QALY gained compared with no screening. The probability of the screening strategy to be cost-effective was 98.8% at a willingness-to-pay of $27 205. Deterministic sensitivity analyses revealed the ICERs were from $4602 to $1...Continue Reading

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Citations

Jul 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Miao-Hui HuangShan-Chwen Chang
Apr 17, 2020·Current Medical Research and Opinion·Do Young KimHyung Joon Kim
Dec 7, 2021·Applied Health Economics and Health Policy·Paul G CartyMairin Ryan

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