Cost-effectiveness and safety of telaprevir and boceprevir for chronic hepatitis C in real-world clinical practice

Gastroenterología y hepatología
Álvaro Giménez-ManzorroGerardo Clemente-Ricote

Abstract

Triple therapy with telaprevir or boceprevir has proven to be effective in the treatment of chronic hepatitis C with response rates of up to 88%. However, the treatment may be associated with important adverse effects and a high economic impact. To assess the cost-effectiveness and safety of triple therapy with telaprevir or boceprevir for the treatment of chronic hepatitis C. Retrospective observational study. We included all patients who had started treatment with protease inhibitors before July 31(st), 2013. We evaluated sustained virological response, the cost per patient achieving sustained virological response, and the cost of the supportive treatment for adverse events associated with triple therapy. Fifty-nine patients were included; 35 had been treated with telaprevir (59.3%) and 24 with boceprevir (40.7%). Sustained virological response was achieved by 38 (64.4%) patients: 24 (68.6%) patients in the telaprevir treatment arm and 14 (58.3%) patients in the boceprevir treatment arm. The cost per patient with sustained virological response was 43,555 € (95% CI 35,389-51,722 €). There were no statistically significant differences between the overall costs of therapy with telaprevir, 43,494 € (95% CI 34,795 €-55,092 €) vers...Continue Reading

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Citations

Feb 19, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Timothy A Bach, Kathy Zaiken
Feb 16, 2020·International Journal of Environmental Research and Public Health·Elizabeth Parody-RúaIgnacio Aznar-Lou
Apr 17, 2020·European Journal of Hospital Pharmacy. Science and Practice·Luis Margusino-FramiñánÁngeles Castro-Iglesias
Oct 2, 2016·Clinical Liver Disease·Omar Y MousaVictor Ankoma-Sey

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