Cost-effectiveness model for neovascular age-related macular degeneration: comparing early and late treatment with pegaptanib sodium based on visual acuity

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Jonathan C JavittAnthony P Adamis

Abstract

To compare the cost-effectiveness of pegaptanib and usual care within three distinct cohorts of subfoveal neovascular age-related macular degeneration (NV-AMD) patients, that is, those with early, moderate, and late disease, using a comprehensive economic model. A Markov framework was used to model lifetime movement of a subfoveal NV-AMD cohort through health states based on visual acuity. The model takes a US payer perspective of patients over the age of 65 years. Clinical efficacy was based on published results for the 0.3 mg pegaptanib and usual care groups. Expert interviews were conducted to determine adverse event treatment patterns and vision rehabilitation resource use. Incidence and costs of comorbidities such as depression and fractures associated with the effects of declining visual acuity were based on our previously published analysis of Medicare data. Transition probabilities were derived from published clinical trial data for each 3-month cycle. Utilities were derived from published sources. Three runs of the model were conducted with cohorts of newly diagnosed patients. Patients were classified as having early, moderate, or late NV-AMD defined as visual acuity in the better-seeing eye of 20/40 to more than 20/80...Continue Reading

References

Jul 1, 1991·European Journal of Epidemiology·A HofmanF A van den Ouweland
Sep 11, 1999·American Journal of Ophthalmology·C M MangioneJ M Seddon
Jan 15, 2000·Archives of Ophthalmology·G C BrownJ Kistler
Apr 13, 2002·Drugs & Aging·Morten la CourMogens Holst Nissen
Jul 18, 2002·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·R LegoodC Cryer
Aug 1, 2002·Archives of Ophthalmology·Barry W RovnerWilliam S Tasman
Jan 22, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Milton C WeinsteinUNKNOWN ISPOR Task Force on Good Research Practices--Modeling Studies
Feb 18, 2003·Journal of the American Geriatrics Society·Rebecca Q IversAnthony J Peduto
Dec 24, 2003·Investigative Ophthalmology & Visual Science·Ee-Munn ChiaPaul Mitchell
Apr 14, 2004·Archives of Ophthalmology·David S FriedmanUNKNOWN Eye Diseases Prevalence Research Group
Dec 31, 2004·The New England Journal of Medicine·Evangelos S GragoudasUNKNOWN VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group
Jun 11, 2005·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Sanjay SharmaGaurav K Shah
Jul 11, 2006·Ophthalmology·UNKNOWN VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial GroupManju Patel
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Francesco BandelloGilles Berdeaux

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Citations

Sep 12, 2008·Cost Effectiveness and Resource Allocation : C/E·Susan F HurleyRobyn H Guymer
Jan 20, 2011·PharmacoEconomics·Paul MitchellSimu Thomas
Jul 16, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·William HodgeAndra Morrison
Nov 14, 2015·PharmacoEconomics·Jordana K Schmier, Carolyn K Hulme-Lowe
Sep 18, 2016·Applied Health Economics and Health Policy·Thomas ButtGary Rubin
Nov 30, 2011·Ophthalmic Research·Elena Prokofyeva, Eberhart Zrenner
Oct 30, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Angelica LyMichael Kalloniatis
Aug 30, 2014·The Cochrane Database of Systematic Reviews·Sharon D SolomonBarbara S Hawkins
Mar 6, 2019·The Cochrane Database of Systematic Reviews·Sharon D SolomonBarbara S Hawkins

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