Cost-effectiveness of a tailored Helicobacter pylori eradication strategy based on the presence of a 23S ribosomal RNA point mutation that causes clarithromycin resistance in Korean patients

Journal of Gastroenterology and Hepatology
Jun-Hyung ChoSuyeon Park

Abstract

The Helicobacter pylori eradication rate using conventional triple therapy has decreased due to clarithromycin (CAM) resistance in H. pylori. Recently, dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) can be used to detect H. pylori and point mutations in the 23S ribosomal RNA gene causing CAM resistance. This study aimed to evaluate the success rate and cost-effectiveness of tailored H. pylori eradication using DPO-PCR. The H. pylori-positive patients diagnosed by a rapid urease test or DPO-PCR were enrolled from a single academic hospital. The patients with positive rapid urease test results received a CAM-based triple regimen. In the tailored therapy group that underwent DPO-PCR testing, patients with A2142G and/or A2143G point mutations were treated with a bismuth-containing quadruple regimen. The cost-effectiveness of H. pylori eradication success was evaluated according to the average cost per patient and the incremental cost-effectiveness ratio. A total of 243 patients were allocated to the triple therapy group and 124 patients to the tailored therapy group. The first-line eradication rate of H. pylori was significantly higher in the tailored therapy group than in the conventional triple...Continue Reading

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Citations

Feb 28, 2019·Journal of Gastroenterology and Hepatology·Young Kwon ChoiHwoon-Yong Jung
Aug 23, 2019·Current Opinion in Gastroenterology·Erick A Argueta, Steven F Moss
Jan 14, 2020·Chinese Medical Journal·Yi HuNong-Hua Lu
Jan 31, 2019·Frontiers in Pharmacology·Mitsushige Sugimoto, Yoshio Yamaoka
Jul 29, 2020·Antibiotics·Su Young Kim, Jun-Won Chung
Sep 6, 2019·Helicobacter·Athanasios MakristathisEmilie Bessède
May 22, 2019·Helicobacter·Jeong Hoon LeeUNKNOWN Upper Gastrointestinal Research
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Jan 13, 2021·Antibiotics·Paula Rojas GarcíaFernando Antoñanzas
Nov 27, 2020·Therapeutic Advances in Gastroenterology·Javier P Gisbert
Jan 21, 2021·Gut and Liver·Hye-Kyung JungUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
Jun 8, 2021·The Korean Journal of Internal Medicine·Hye-Kyung JungUNKNOWN Korean College of Helicobacter and Upper Gastrointesinal Research

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