Cost-effectiveness of acromegaly treatments: a systematic review

Pituitary
L P LeonartR Pontarolo

Abstract

Acromegaly is a rare disease that results in the enlargement of body extremities and in organomegaly. Treatments include surgery, drugs, and radiotherapy, which are all onerous. Therefore, well-conducted cost-analyses are crucial in the decision-making process. A systematic review of cost-effectiveness studies on acromegaly therapies was performed following PRISMA and Cochrane recommendations. The search for records was conducted in PubMed, Scopus, and Web of Science (May 2018). The quality of the included studies was assessed using the Joana Briggs Institute Tool. From initial 547 records, 16 studies were included in the review. The studies could present more than one economic evaluation, and encompassed cost-effectiveness (n = 13), cost-utility (n = 5), and cost-consequence (n = 1) analyses. All studies were model-based and evaluated only direct medical costs. Eleven records did not mention discounting and only 10 performed sensitivity analyses. The characteristic of the studies, the cost-effectiveness results and the studies' conclusions are described and commented upon. The main limitation of the studies was discussed and aspects to improve in future studies were pointed out. Cost-effectiveness studies on acromegaly have be...Continue Reading

References

May 12, 2005·The Journal of Clinical Endocrinology and Metabolism·Pamela U FredaDaniel Rabinowitz
Dec 14, 2007·Reviews in Endocrine & Metabolic Disorders·John Ayuk, Michael C Sheppard
May 15, 2008·The Journal of Clinical Endocrinology and Metabolism·Robert D Murray, Shlomo Melmed
Feb 7, 2009·Arquivos brasileiros de endocrinologia e metabologia·Joice ValentimAlessandra Calabró
Apr 30, 2009·Annual Review of Pathology·Sylvia L Asa, Shereen Ezzat
Jun 17, 2009·Expert Review of Pharmacoeconomics & Outcomes Research·Nienke R BiermaszJohannes A Romijn
Nov 4, 2009·The Journal of Clinical Investigation·Shlomo Melmed
Dec 17, 2009·Pituitary·William T Couldwell, Lisa Cannon-Albright
Feb 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Laure SandretPhilippe Chanson
Jun 26, 2012·Journal of Neurosurgery·Nicholas F MarkoRobert J Weil
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Don HusereauUNKNOWN ISPOR Health Economic Evaluation Publication Guidelines-CHEERS Good Reporting Practices Task Force
Feb 26, 2014·Nature Reviews. Endocrinology·Andrea GiustinaUNKNOWN Acromegaly Consensus Group
Oct 31, 2014·The Journal of Clinical Endocrinology and Metabolism·Laurence KatznelsonJohn A H Wass
Jan 6, 2015·Pituitary·Kristopher T KimmellNicholas F Marko
Aug 20, 2015·International Journal of Evidence-based Healthcare·Judith Streak GomersallAlin Preda
Aug 25, 2015·European Journal of Internal Medicine·Luis Margusino-FramiñánFernando Cordido
Nov 5, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·J HahlK Snicker
Apr 20, 2016·European Journal of Endocrinology·Cesar Luiz Boguszewski, John Ayuk

❮ Previous
Next ❯

Citations

May 6, 2019·Expert Review of Pharmacoeconomics & Outcomes Research·Carmen PeralCarlos Rubio-Terrés
Mar 20, 2021·Hormones : International Journal of Endocrinology and Metabolism·Kiyohiko SakataMotohiro Morioka
Apr 17, 2020·Neuroendocrinology·Leticia P LeonartRoberto Pontarolo
Jan 16, 2022·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Dawn Shao Ting Lim, Maria Fleseriu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved