PMID: 8957728Dec 1, 1996Paper

Cost effectiveness of adjuvant intraportal chemotherapy in patients with colorectal cancer

Journal of Clinical Gastroenterology
A MessoriE Tendi

Abstract

Recent studies have shown that the analysis of published survival curves allows cost-effectiveness evaluations in which two treatments are compared with each other in terms of cost per life-year saved. In patients with colorectal cancer, the administration of adjuvant intraportal chemotherapy (with mitomycin and fluorouracil) has been reported to improve long-term survival in comparison with patients who are not given this treatment. To assess the pharmacoceconomic profile of this adjuvant chemotherapy, we carried out an incremental cost-effectiveness analysis in which we used the Gompertz model to estimate lifetime patient years gained by patients given this chemotherapy in comparison with controls. Using the data of a published controlled long-term trial involving 252 patients treated with intraportal chemotherapy and 253 controls who were given no such therapy, we estimated that the adjuvant treatment improved life expectancy by 89 discounted patient years (or 218 undiscounted patient years) every 100 patients. Cost of chemotherapy was calculated as $107,720 for every 100 patients. On the basis of these data, the administration of adjuvant intraportal chemotherapy was found to imply an incremental cost of $1,210 per discount...Continue Reading

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Citations

Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W B van den HoutJ Kievit
Aug 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MessoriE Tendi
Dec 1, 1996·Journal of Clinical Gastroenterology·W M Tierney, A M Fendrick
Sep 22, 2005·PharmacoEconomics·J M BosLieven Annemans
Aug 25, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Matteo RuggeriAmerico Cicchetti
May 7, 1998·Quality in Health Care : QHC·A MelvilleA Sowden

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