Cost-Effectiveness of Administering Rituximab for Steroid-Dependent Nephrotic Syndrome and Frequently Relapsing Nephrotic Syndrome: A Preliminary Study in Japan

Scientific Reports
Tomoyuki TakuraKosaku Nitta

Abstract

With regard to the use of rituximab for patients with steroid-dependent nephrotic syndrome and frequently relapsing nephrotic syndrome, not only has the regimen not been clinically verified but also there is a lack of health economics evidence. Therefore, we conducted a prospective clinical study on 30 patients before (with steroids and immunosuppressants) and after introducing rituximab therapy. Relapse rates and total invoiced medical expenses were selected as the primary endpoints for treatment effectiveness and treatment costs, respectively. As secondary endpoints, cost-effectiveness was compared before and after administering rituximab in relation to previous pharmacotherapy. The observation period was 24 months before and after the initiation of rituximab. We showed that there was a statistically significant improvement in the relapse rate from a mean of 4.30 events before administration to a mean of 0.27 events after administration and that there was a significantly better prognosis in the cumulative avoidance of relapse rate by Kaplan-Meier analysis (p < 0.01). Finally, the total medical costs decreased from 2,923 USD to 1,280 USD per month, and the pre-post cost-effectiveness was confirmed as dominant. We, therefore, c...Continue Reading

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Citations

Dec 28, 2017·Internal Medicine·Tomoyuki Takura
Sep 3, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Franca IoremberOluwatoyin Bamgbola
May 28, 2019·Frontiers in Pediatrics·Mahmoud KallashJohn D Mahan
Oct 24, 2020·Obstetric Medicine·Francesca HoldenKatherine Clark
Jun 12, 2021·Archives of Disease in Childhood·Rajiv SinhaStephen D Marks

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