Cost-effectiveness of clostridial collagenase ointment on wound closure in patients with diabetic foot ulcers: economic analysis of results from a multicenter, randomized, open-label trial

Journal of Foot and Ankle Research
Travis A MotleyJaime E Dickerson

Abstract

Approximately 10%-15% of people with diabetes develop at least one foot ulcer during their lifetime. Treatment of diabetic foot ulcers (DFUs) represents a significant economic burden. Enzymatic debridement with clostridial collagenase ointment (CCO) can be used to remove necrotic tissue from wounds. This study examined the impact of CCO as an effective adjunct therapy to serial sharp debridement (SSD) and assessed the cost-effectiveness of CCO compared with standard DFU treatments over 1 year. Adults 18 years or older with a diagnosis of type 1 or type 2 diabetes who had a neuropathic DFU were enrolled in a 12-week, randomized, open-label trial. Patients were randomly assigned to either treatment with CCO + SSD or to investigator-selected supportive care + SSD (Control). A 3-state Markov model with a 1-week cycle length was developed using wound-closure rates from the trial to estimate the number of healed-wound weeks and the expected DFU cost per patient. The 3 states included unhealed, healed, and death. Results were extrapolated to 1 year to estimate the number of healed-wound weeks per treatment and the average cost to achieve epithelialization. The perspective of the analysis was that of the payer, specifically, the third ...Continue Reading

Associated Clinical Trials

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Citations

Apr 26, 2017·International Wound Journal·Jérôme Patry, Virginie Blanchette
Jun 28, 2017·Plastic and Reconstructive Surgery·Christine M JonesDonald R Mackay
Oct 28, 2017·Journal of Comparative Effectiveness Research·Curtis WaycasterCatherine T Milne
Apr 13, 2018·Advances in Wound Care·Caroline E FifeMarissa J Carter
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May 2, 2017·Journal of Diabetes Research·Jing ZhaoTing Gong
Jan 30, 2018·Annals of the New York Academy of Sciences·Estelle Everett, Nestoras Mathioudakis
Feb 3, 2021·The International Journal of Lower Extremity Wounds·Moein KardoustAhmadreza Sayadi
Jan 1, 2018·Anais Brasileiros De Dermatologia·Raquel Colenci, Luciana Patricia Fernandes Abbade
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou

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Methods Mentioned

BETA
amputation

Clinical Trials Mentioned

NCT01408277

Software Mentioned

TreeAge Pro
TreeAge

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