Cost-Effectiveness of Competing Treatment Strategies for Clostridium difficile Infection: A Systematic Review

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Phuc LeAbhishek Deshpande

Abstract

BACKGROUND Clostridium difficile infection (CDI) presents a substantial economic burden and is associated with significant morbidity. While multiple treatment strategies have been evaluated, a cost-effective management strategy remains unclear. OBJECTIVE We conducted a systematic review to assess cost-effectiveness analyses of CDI treatment and to summarize key issues for clinicians and policy makers to consider. METHODS We searched PubMed and 5 other databases from inception to August 2016. These searches were not limited by study design or language of publication. Two reviewers independently screened the literature, abstracted data, and assessed methodological quality using the Drummond and Jefferson checklist. We extracted data on study characteristics, type of CDI, treatment characteristics, and model structure and inputs. RESULTS We included 14 studies, and 13 of these were from high-income countries. More than 90% of these studies were deemed moderate-to-high or high quality. Overall, 6 studies used a decision-tree model and 7 studies used a Markov model. Cost of therapy, time horizon, treatment cure rates, and recurrence rates were common influential factors in the study results. For initial CDI, fidaxomicin was a more c...Continue Reading

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Citations

Oct 28, 2018·PharmacoEconomics·Edward T ChiyakaPhuc Le
Jan 25, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Thomas StalderVirginie Nerich
Apr 20, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Radha RajasinghamByron P Vaughn
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Dec 11, 2021·Pediatric Annals·Jacob M ParnellStacy A Kahn

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