Cost-effectiveness of cytomegalovirus (CMV) disease prevention in patients with AIDS: oral ganciclovir and CMV polymerase chain reaction testing

AIDS
D N Rose, H S Sacks

Abstract

To perform a cost-effectiveness analysis of strategies to prevent cytomegalovirus (CMV) disease. Markov model and published data. Hypothetical HIV-infected patients with CD4 cell counts < or = 50 x 10(6)/l and positive CMV serologies. Oral ganciclovir daily versus plasma CMV DNA polymerase chain reaction (PCR) testing every 3 months with oral ganciclovir for patients with positive tests. The number of CMV disease cases prevented by the interventions, life expectancy, disease-free life expectancy, and the cost to extend life by 1 year. Oral ganciclovir preventive therapy reduces the lifetime number of CMV disease cases by 50 per 1000 cohort, extends life expectancy by 5 days and disease-free life expectancy by 18 days, and costs US$ 1,762,517 per year of life extended. Periodic PCR testing reduces the lifetime number of CMV disease cases by eight per 1000 cohort, extends life expectancy by 1 day and disease-free life expectancy by 3 days, and costs US$ 495,158 per year of life extended. The prevention strategies could be acceptably cost effective only under a combination of optimistic assumptions and reduced costs. Oral ganciclovir preventive therapy and periodic plasma testing for CMV PCR with oral ganciclovir for those with po...Continue Reading

References

Feb 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W L Drew
Aug 14, 1991·JAMA : the Journal of the American Medical Association·A R Castellano, M D Nettleman
Jan 1, 1983·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J R Beck, S G Pauker
Jun 1, 1995·Risk Analysis : an Official Publication of the Society for Risk Analysis·T O TengsJ D Graham
Nov 1, 1994·The Journal of Infectious Diseases·K K HansenL Mathiesen
Feb 1, 1993·The American Journal of Medicine·D N RoseH S Sacks
Jul 28, 1993·JAMA : the Journal of the American Medical Association·F J Hellinger
Apr 1, 1996·Annals of Internal Medicine·R D Moore, R E Chaisson

❮ Previous
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Citations

Mar 5, 2004·Survey of Ophthalmology·Tamara R Vrabec
Apr 20, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanH Watts
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H SmithC F Decker
Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D PassalarisM J Glesby
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M P DubéUNKNOWN Adult AIDS Clinical Trial Group Cardiovascular Disease Focus Group
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A D PaltielK A Freedberg
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent AaronJean Paul Viard
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael P DubéUNKNOWN HIV Medical Association of the Infectious Disease Society of America
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S WalmsleyT Mazzulli
Feb 24, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S P WhittS Dolan
Aug 23, 2008·The Journal of Antimicrobial Chemotherapy·B RoquebertUNKNOWN French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2)
Nov 25, 2003·QJM : Monthly Journal of the Association of Physicians·U Ravnskov
Apr 30, 2002·Current Opinion in Infectious Diseases·M E Sharkey, M Stevenson
Jul 18, 2003·Nursing Research·Vicki S ConnMarilyn J Rantz
Apr 22, 2003·Orthopaedic Nursing·Marilyn H OermannJo Ann Ashare
Jun 29, 2006·The Pediatric Infectious Disease Journal·Jeanne BertolliUNKNOWN Pediatric Spectrum of HIV Disease Study
May 24, 2000·Journal of Clinical Pathology·M Helbert, J Breuer
Jul 19, 2001·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·W KippJ Konde-Lule
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Das
Dec 7, 2007·Medical Decision Making : an International Journal of the Society for Medical Decision Making·John HornbergerEric Verhulst
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A D PaltielK A Freedberg
Jul 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina SinghAjit P Limaye
Oct 28, 1999·Archives of Pathology & Laboratory Medicine·J S Ross

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