Cost-Effectiveness of Dengue Vaccination Programs in Brazil

The American Journal of Tropical Medicine and Hygiene
Eunha Shim

Abstract

AbstractThe first approved dengue vaccine, CYD-TDV, a chimeric, live-attenuated, tetravalent dengue virus vaccine, was recently licensed in 13 countries, including Brazil. In light of recent vaccine approval, we modeled the cost-effectiveness of potential vaccination policies mathematically based on data from recent vaccine efficacy trials that indicated that vaccine efficacy was lower in seronegative individuals than in seropositive individuals. In our analysis, we investigated several vaccination programs, including routine vaccination, with various vaccine coverage levels and those with and without large catch-up campaigns. As it is unclear whether the vaccine protects against infection or just against disease, our model incorporated both direct and indirect effects of vaccination. We found that in the presence of vaccine-induced indirect protection, the cost-effectiveness of dengue vaccination decreased with increasing vaccine coverage levels because the marginal returns of herd immunity decreases with vaccine coverage. All routine dengue vaccination programs that we considered were cost-effective, reducing dengue incidence significantly. Specifically, a routine dengue vaccination of 9-year-olds would be cost-effective when...Continue Reading

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Citations

Jun 28, 2018·Memórias do Instituto Oswaldo Cruz·Paulo Sousa PradoGustavo Adolfo Sierra Romero
Mar 9, 2019·MicrobiologyOpen·San SuwanmaneeNatthanej Luplertlop
Oct 19, 2019·International Journal of Technology Assessment in Health Care·Sathira PereraBuddhika Senanayaka
Aug 29, 2018·Parasitology Research·Reji GopalakrishnanRam Singh
Jan 7, 2021·Bulletin of Mathematical Biology·Ling XueHuaiping Zhu
Jul 27, 2021·PLoS Neglected Tropical Diseases·Guido EspañaT Alex Perkins
Nov 19, 2021··Chai Jian TayHock Lye Koh

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