Cost-effectiveness of Down syndrome screening paradigms

Clinics in Laboratory Medicine
Aaron B CaugheyAnthony Odibo

Abstract

Methodologic and ethical concerns in the area of prenatal diagnosis include whether the effects of such testing on individuals other than patients are considered, what assumptions are made regarding termination of pregnancy following a diagnosis, whether the redundancy of screening and diagnostic methods is considered, and how the impact of positive or negative screening results on patient experience and anxiety can be quantified. Several studies have examined the cost-effectiveness of screening for Down syndrome (DS). Given the current test characteristics, screening for DS is cost-effective across a wide variety of clinical situations. In fact, contingent screening is potentially a dominant strategy (costs less and leads to better outcomes). Understanding the methodology and salient issues of cost-effectiveness analysis is critical for researchers, editors, and clinicians to accurately interpret results of the growing body of cost-effectiveness studies in prenatal diagnosis.

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Citations

Jun 15, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P BennE Pergament
Sep 7, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ken SongAaron B Caughey
Jan 30, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ken SongAaron B Caughey
Apr 2, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·I MartínJ M Bauça
May 1, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Jeremy D Goldhaber-Fiebert, Margaret L Brandeau
Sep 29, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kelly Kuo, Aaron B Caughey
Oct 16, 2013·Current Opinion in Obstetrics & Gynecology·Maria I Rodriguez, Aaron B Caughey

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