Cost-effectiveness of eradication of Helicobacter pylori in gastric cancer survivors after endoscopic resection of early gastric cancer

Dong Wook ShinSang Min Park


Clinical effectiveness of Helicobacter pylori eradication in gastric cancer survivors after endoscopic resection of early gastric cancer (EGC) was recently established in a randomized controlled trial. We aimed to establish long-term cost-effectiveness in gastric cancer survivors after endoscopic resection of EGC. A Markov model was constructed to compare the costs and outcomes of the two intervention strategies: (1) eradicate H. pylori after complete resection of EGC by endoscopy (2) do not eradicate. Estimates for variables in the model were obtained by extensive review of published reports. Analyses were made from the Korean public healthcare provider's perspective. Base-case analysis indicated H. pylori eradication costs less (US$ 29,780 vs. US$ 30,594) than no eradication, and save more lives (mean life expectancy from eradication: 13.60 years vs. 13.55 years). One-way and three-way sensitivity analyses showed the robustness of the cost-effectiveness results. In this selective population with very high risk of developing gastric cancer, H. pylori eradication should be considered for reimbursement with priority to prevent subsequent cancer and also reduce health care cost.


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Jul 25, 2013·BMC Health Services Research·Kayoko HagaTomonori Hasegawa
Nov 5, 2013·Best Practice & Research. Clinical Gastroenterology·Iris Lansdorp-Vogelaar, Linda Sharp
Jul 26, 2011·Journal of Translational Medicine·Joanna D HolbrookRakesh Kumar
Nov 19, 2019·BioMed Research International·Lan Li, Chaohui Yu
Oct 3, 2020·Gut·Jyh-Ming LiouUNKNOWN Asian Pacific Alliance on Helicobacter and Microbiota (APAHAM)
May 28, 2017·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Shota SaitoKouhei Akazawa

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