Cost-effectiveness of fingolimod versus interferon beta-1a for relapsing remitting multiple sclerosis in the United States

Journal of Medical Economics
Soyon LeeCraig I Coleman

Abstract

Fingolimod has been shown to be more efficacious than interferon (IFN) beta-1a, but at a higher drug acquisition cost. The aim of this study was to assess the cost-effectiveness of fingolimod compared to IFN beta-1a in patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) in the US. A Markov model comparing fingolimod to intramuscular IFN beta-1a using a US societal perspective and a 10-year time horizon was developed. A cohort of 37-year-old patients with RRMS and a Kurtzke Expanded Disability Status Scale score of 0-2.5 were assumed. Data sources included the Trial Assessing Injectable Interferon vs FTY720 Oral in Relapsing-Remitting Multiple Sclerosis (TRANSFORMS) and other published studies of MS. Outcomes included costs in 2011 US dollars, quality-adjusted life years (QALYs), number of relapses avoided, and incremental cost-effectiveness ratios (ICERs). Compared to IFN beta-1a, fingolimod was associated with fewer relapses (0.41 vs 0.73 per patient per year) and more QALYs gained (6.7663 vs 5.9503), but at a higher cost ($565,598 vs $505,234). This resulted in an ICER of $73,975 per QALY. Results were most sensitive to changes in drug costs and the disutility of receiving IFN beta-1a. Monte Carlo simulation...Continue Reading

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Citations

Nov 30, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Harold L Atkins, Mark S Freedman
Aug 22, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·R Brett McQueenJonathan D Campbell
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Jan 26, 2017·Journal of Comparative Effectiveness Research·Aseel Bin SawadFatema Turkistani
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Jan 22, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Surachat Ngorsuraches, Nabin Poudel
Feb 3, 2020·Multiple Sclerosis and Related Disorders·Staley A Brod
May 17, 2021·Multiple Sclerosis and Related Disorders·Staley A Brod

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