Cost effectiveness of gene expression profiling for early stage breast cancer: a decision-analytic model

Cancer
Mo YangAmalia M Issa

Abstract

Gene expression profiling (GEP) is being used increasingly for risk stratification to identify women with lymph node-negative, estrogen receptor-positive, early stage breast cancer who are most likely to benefit from adjuvant chemotherapy. The authors of this report evaluated the cost effectiveness of recurrence score-guided treatment using 2 commercially available GEP tests, Oncotype DX (Genomic Health, Redwood City, Calif) and MammaPrint (Agendia Inc., Irvine, Calif), from a third-party payer's perspective. A 10-year Markov model was developed to compare the costs and quality-adjusted life-years (QALYs) of treatment decisions guided by either Oncotype DX or MammaPrint in a hypothetical cohort of women with early stage, lymph node-negative, estrogen receptor-positive breast cancer who may experience recurrence. Outcomes included no recurrence, recurrence, and death. The costs considered included gene test costs, the costs of adjuvant chemotherapy and other chemotherapy (including premedication, oncology visits, and monitoring for adverse events), the cost of treating recurrence, costs associated with the treatment of adverse events, and end-of-life care costs. The model demonstrated that the patients who received the Oncotype ...Continue Reading

References

Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A SawkaD Harrison-Woermke
Oct 9, 1996·JAMA : the Journal of the American Medical Association·L B RussellM C Weinstein
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E HillnerT J Smith
Jun 8, 2000·Medical Care·T O Tengs, A Wallace
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C C EarleP J Neumann
Jun 30, 2001·The New England Journal of Medicine·C L Shapiro, A Recht
Jul 30, 2003·Archives of Internal Medicine·Peter A UbelA Mark Fendrick
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena B ElkinJane C Weeks
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Jul 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nina OestreicherDavid L Veenstra
May 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Soonmyung PaikNorman Wolmark
Sep 7, 2006·Journal of the National Cancer Institute·Marc BuyseUNKNOWN TRANSBIG Consortium
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicola Lucio LiberatoGiovanni Barosi
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allison W KurianAlan M Garber
Feb 7, 2008·Annals of Internal Medicine·Luigi MarchionniSteven N Goodman
Jun 19, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jul 8, 2009·Expert Review of Molecular Diagnostics·Elzbieta A Slodkowska, Jeffrey S Ross
Sep 4, 2009·The New England Journal of Medicine·Yue-Can Zeng
Apr 1, 2003·Journal of the National Comprehensive Cancer Network : JNCCN·Charles L Loprinzi, Peter M Ravdin
Apr 3, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Valesca P RetèlWim H van Harten
Apr 24, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Shmuel H KlangJohn Hornberger
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward

❮ Previous
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Citations

Jun 1, 2013·Breast Cancer Research and Treatment·Roman RouzierWilliam J Valentine
Aug 29, 2012·Journal of Cancer Epidemiology·Teri L MaloSusan T Vadaparampil
Mar 24, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·Miguel Angel SeguíAlfredo Gracia
Sep 13, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Miguel Ángel SeguíAlfredo Gracia
Nov 14, 2015·Expert Review of Molecular Diagnostics·Monica SagerJimmy Lin
Sep 30, 2015·The FEBS Journal·Rafael Moreno-SánchezSara Rodríguez-Enríquez
Nov 4, 2015·Journal of Comparative Effectiveness Research·Lorena San Miguel, Frank Hulstaert
Jan 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J ReeveP F Halloran
Jul 23, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Laura ZanottiMaria Rosa Cappelletti
Jun 5, 2014·Pharmacogenomics·Michael J SorichBrita Pekarsky
Sep 27, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·W Ken Redekop, Deirdre Mladsi
Apr 2, 2014·The Breast : Official Journal of the European Society of Mastology·P G CusumanoM Lutke Holzik
Jun 21, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sophie MarguetJulia Bonastre
Aug 31, 2016·Breast Cancer Research and Treatment·Virginie NerichBernhard Holzner
Oct 28, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Anirban BasuDavid L Veenstra
Apr 8, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dron GauchanSitki M Copur
Nov 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J EpsteinPeter W Groeneveld
Jun 1, 2017·Nature Reviews. Clinical Oncology·Maryann KwaFrancisco J Esteva
Oct 20, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Beate JahnUwe Siebert
Dec 12, 2012·Thrombosis and Haemostasis·Erya HuangDmitri V Gnatenko
Feb 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J SellarésP F Halloran
Aug 30, 2018·Future Oncology·Mariana BrandãoMartine Piccart-Gebhart
Aug 7, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P F HalloranJ Reeve
Sep 5, 2014·The Oncologist·Christina AdanielFrancisco J Esteva
Jun 9, 2020·JCO Global Oncology·Gouri Shankar BhattacharyyaS P Somashekhar
Jul 14, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S Pérez RamírezM Martín
Oct 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P F HalloranJ Reeve
Nov 1, 2013·Personalized Medicine·Leonie Jm DelahayeAnnuska M Glas

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