Cost-effectiveness of HPV vaccination regime: comparing twice versus thrice vaccinations dose regime among adolescent girls in Malaysia

BMC Public Health
Syed AljunidSharifa Ezat Wan Puteh

Abstract

The HPV vaccine was introduced to Malaysian national immunization programme in 2010. The current implementation age of HPV vaccination in Malaysian is at the age of 13 years school girls, given according to a 3 doses protocol which may complicate implementation and compliance. Aim of the study is to determine the cost-effectiveness of HPV vaccination regime comparing twice versus thrice HPV vaccinations dose regime among adolescent girls in Malaysia. A Markov cohort model reflecting the natural history of HPV infection accounting for oncogenic and low-risk HPV was adapted for 13 year old Malaysian girls cohort (n = 274,050). Transition probabilities, utilities values, epidemiological and cost data were sourced from published literature and local data. Vaccine effectiveness was based on overall efficacy reported from 3-doses clinical trials, with the assumption that the 2-doses is non-inferior to the 3-doses allowing overall efficacy to be inferred from the 3-doses immunogenicity data. Price parity and life-long protection were assumed. The payer perspective was adopted, with appropriate discounting for costs (3 %) and outcomes (3 %). One way sensitivity analysis was conducted. The sensitivity analysis on cost of vaccine, vaccin...Continue Reading

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Mar 21, 2007·Emerging Infectious Diseases·Elamin H ElbashaRalph P Insinga
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Citations

Jul 28, 2020·International Journal of Public Health·Saba AbidiPuneeta Ajmera
Dec 12, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Mireia DiazLaia Bruni
Nov 8, 2019·Value in Health Regional Issues·Ku Nurhasni Ku Abd RahimSharifa Ezat Wan Puteh
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xin Liu

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