Cost-Effectiveness of Injectable Extended-Release Naltrexone Compared With Methadone Maintenance and Buprenorphine Maintenance Treatment for Opioid Dependence

Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse
Heide JacksonDavid J Vanness

Abstract

The aim of this study was to estimate the cost-effectiveness of injectable extended-release naltrexone (XR-NTX) compared with methadone maintenance and buprenorphine maintenance treatment (MMT and BMT, respectively) for adult males enrolled in treatment for opioid dependence in the United States from the perspective of state-level addiction treatment payers. A Markov model with daily time cycles was used to estimate the incremental cost per opioid-free day in a simulated cohort of adult males aged 18-65 over a 6-month period from the state health program perspective. XR-NTX is predicted to be more effective and more costly than methadone or buprenorphine in our target population, with an incremental cost per opioid-free day gained relative to the next-most effective treatment (MMT) of $72. The cost-effectiveness of XR-NTX relative to MMT was driven by its effectiveness in deterring opioid use while receiving treatment. XR-NTX is a cost-effective medication for treating opioid dependence if state addiction treatment payers are willing to pay at least $72 per opioid-free day.

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Citations

Jan 13, 2018·Journal of Medical Economics·Ankit ShahMugdha Gore
Sep 3, 2019·Addiction Science & Clinical Practice·Paxton Bach, Daniel Hartung
Mar 24, 2016·PharmacoEconomics·Sean M Murphy, Daniel Polsky
May 25, 2018·Harm Reduction Journal·Jose Luis BurgosNatasha K Martin
Sep 30, 2020·Drug and Alcohol Dependence·Gary A ZarkinRobert P Schwartz
Feb 2, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Elizabeth BeaulieuMohammad S Jalali
Aug 3, 2019·Journal of Substance Abuse Treatment·Iuliia MakarenkoFrederick L Altice
Aug 24, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Carolina BarbosaGary Zarkin
Aug 18, 2021·The American Journal of Drug and Alcohol Abuse·Lien-Chung Wei, Hung-Yu Chan

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Methods Mentioned

BETA
pharmacotherapies
pharmacotherapy

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