Cost-effectiveness of insulin aspart versus human soluble insulin in type 2 diabetes in four European countries: subgroup analyses from the PREDICTIVE study

Current Medical Research and Opinion
James L PalmerStéphane Roze

Abstract

To evaluate the long-term health economic outcomes associated with insulin aspart (IAsp) compared to human soluble insulin (HI) in type 2 diabetes patients on basal-bolus therapy in Sweden, Spain, Italy and Poland. A published computer simulation model of diabetes was used to predict life expectancy, quality-adjusted life expectancy and incidence of diabetes-related complications. Baseline cohort characteristics (age 61.6 years, duration of diabetes 13.2 years, 45.1% male, HbA(1c) 8.2%, BMI 29.8 kg/m(2)) and treatment effects were derived from the PREDICTIVE observational study. Country-specific complication costs were derived from published sources. The analyses were run over 35-year time horizons from third-party payer perspectives in Spain, Italy and Poland and from a societal perspective in Sweden. Future costs and clinical benefits were discounted at country-specific discount rates. Sensitivity analyses were performed. IAsp was associated with improvements in discounted life expectancy and quality-adjusted life expectancy, and a reduced incidence of most diabetes-related complications versus HI in all four settings. IAsp was associated with societal cost-savings in Sweden (SEK 2470), direct medical cost-savings in Sweden a...Continue Reading

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Citations

May 9, 2012·Journal of Medical Economics·J Smith-PalmerW J Valentine
Oct 19, 2016·PharmacoEconomics·Asrul Akmal ShafieNathorn Chaiyakunapruk
Dec 6, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Johan JendleRichard F Pollock
May 7, 2021·ClinicoEconomics and Outcomes Research : CEOR·Beatriz Rodriguez-SanchezJulio Lopez-Bastida

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