Cost-effectiveness of mechanical thrombectomy within 6 hours of acute ischaemic stroke in China

BMJ Open
Yuesong PanYilong Wang

Abstract

Endovascular mechanical thrombectomy is an effective but expensive therapy for acute ischaemic stroke with proximal anterior circulation occlusion. This study aimed to determine the cost-effectiveness of mechanical thrombectomy in China, which is the largest developing country. A combination of decision tree and Markov model was developed. Outcome and cost data were derived from the published literature and claims database. The efficacy data were derived from the meta-analyses of nine trials. One-way and probabilistic sensitivity analyses were performed in order to assess the uncertainty of the results. Hospitals in China. The patients with acute ischaemic stroke caused by proximal anterior circulation occlusion within 6 hours. Mechanical thrombectomy within 6 hours with intravenous tissue plasminogen activator (tPA) treatment within 4.5 hours versus intravenous tPA treatment alone. The benefit conferred by the treatment was assessed by estimating the cost per quality-adjusted life-year (QALY) gained in the long term (30 years). The addition of mechanical thrombectomy to intravenous tPA treatment compared with standard treatment alone yielded a lifetime gain of 0.794 QALYs at an additional cost of CNY 50 000 (US$7700), resultin...Continue Reading

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Citations

Feb 6, 2020·Stroke; a Journal of Cerebral Circulation·Yuesong PanYongjun Wang
Oct 5, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Anderson Chun On TsangSong Huang
Jan 12, 2021·Stroke; a Journal of Cerebral Circulation·Paolo CandioRamon Luengo-Fernandez
Feb 12, 2021·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yuliang XiangMing Hu
Feb 9, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Muhammad WaqasElad I Levy
Jan 13, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Laura K SevickUNKNOWN ESCAPE Trialists
Nov 4, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Ana Claudia de SouzaRaul G Nogueira

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