Cost-effectiveness of newborn screening for severe combined immunodeficiency

European Journal of Pediatrics
Catharina P B Van der PloegM Elske van den Akker-van Marle

Abstract

Severe combined immunodeficiency (SCID) is a condition that often results in severe infections and death at young age. Early detection shortly after birth, followed by treatment before infections occur, largely increases the chances of survival. As the incidence of SCID is low, assessing cost-effectiveness of adding screening for SCID to the newborn screening program is relevant for decision making. Lifetime costs and effects of newborn screening for SCID were compared to a situation without screening in the Netherlands in a decision analysis model. Model parameters were based on literature and expert opinions. Sensitivity analyses were performed. Due to earlier detection, the number of deaths due to SCID per 100,000 children was assessed to decrease from 0.57 to 0.23 and a number of 11.7 quality adjusted life-years (QALYs) gained was expected. Total yearly healthcare costs, including costs of screening, diagnostics, and treatment, were €390,800 higher in a situation with screening compared to a situation without screening, resulting in a cost-utility ratio of €33,400 per QALY gained.Conclusion: Newborn screening for SCID might be cost-effective. However, there is still a lot of uncertainty around the cost-effectiveness estimat...Continue Reading

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Citations

Sep 8, 2020·European Journal of Public Health·Catharina P B Van der PloegPaul H Verkerk
Oct 18, 2019·Frontiers in Pediatrics·Mirjam van der BurgSung-Yun Pai
Aug 30, 2019·International Journal of Neonatal Screening·Alice BesseyRuth Wong
Nov 27, 2020·International Journal of Neonatal Screening·Pasquale CacciatoreM Elske van den Akker-van Marle

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