Cost-effectiveness of omalizumab for the treatment of chronic spontaneous urticaria

The British Journal of Dermatology
T A KantersL Hakkaart

Abstract

Chronic spontaneous urticaria (CSU) is a skin disease with itchy hives and/or angio-oedema that last for at least 6 weeks without an obvious external trigger. To determine the cost-effectiveness of omalizumab relative to standard of care (SoC; up to four times the daily dose of H1 -antihistamines) in the Netherlands from a societal perspective. The Markov model used consisted of five health states based on Urticaria Activity Score over 7 days. Model settings and characteristics of the Dutch patient population were based on an online survey among clinical experts and were validated during an expert committee meeting. Transition probabilities were derived from the GLACIAL trial. Healthcare consumption, quality of life (using EuroQol-5D) and productivity losses were derived from a burden-of-illness study (ASSURE-CSU) among 93 Dutch patients. Healthcare consumption and productivity losses were evaluated using the Dutch costing manual. The comparator treatment was SoC, consisting of (updosed) antihistamines. A 10-year time horizon was used. The incremental cost-effectiveness ratio (ICER) of omalizumab vs. SoC was €17 502 per quality-adjusted life-year (QALY) gained. Productivity costs played an important role in the value of the ICE...Continue Reading

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Citations

Jul 14, 2020·Allergy·Pauline AzzanoPhilippe Bégin
Oct 9, 2020·The Journal of Dermatology·Daiki MatsubaraMichihiro Hide
Sep 22, 2020·The British Journal of Dermatology·M GonçaloM Maurer
Jul 6, 2020·Journal of the American Academy of Dermatology·Sofianne GabrielliMoshe Ben-Shoshan
Apr 6, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Hilary J LonghurstLuis F Ensina
Jan 29, 2019·The Journal of Allergy and Clinical Immunology·Juan Carlos Cardet, Thomas B Casale
Feb 9, 2020·Annales de dermatologie et de vénéréologie·E Delaporte

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