PMID: 25798150Mar 24, 2015Paper

Cost effectiveness of 'on demand' HIV pre-exposure prophylaxis for non-injection drug-using men who have sex with men in Canada

The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale
Estelle OuelletCécile L Tremblay

Abstract

Recent trials report the efficacy of continuous tenofovir-based pre-exposure prophylaxis (PrEP) for prevention of HIV infection. The cost effectiveness of 'on demand' PrEP for non-injection drug-using men who have sex with men at high risk of HIV acquisition has not been evaluated. To conduct an economic evaluation of the societal costs of HIV in Canada and evaluate the potential benefits of this PrEP strategy. Direct HIV costs comprised outpatient, inpatient and emergency department costs, psychosocial costs and antiretroviral costs. Resource consumption estimates were derived from the Centre Hospitalier de l'Université de Montréal HIV cohort. Estimates of indirect costs included employment rate and work absenteeism. Costs for 'on demand' PrEP were modelled after an ongoing clinical trial. Cost-effectiveness analysis compared costs of 'on demand' PrEP to prevent one infection with lifetime costs of one HIV infection. Benefits were presented in terms of life-years and quality-adjusted life-years. The average annual direct cost of one HIV infection was $16,109 in the least expensive antiretroviral regimen scenario and $24,056 in the most expensive scenario. The total indirect cost was $11,550 per year. Total costs for the first ...Continue Reading

Citations

Nov 17, 2015·Current Opinion in HIV and AIDS·Valentina CambianoAndrew Phillips
Dec 7, 2017·AIDS·Isabelle Durand-ZaleskiUNKNOWN ANRS IPERGAY Study Group
May 31, 2019·The Journal of Pharmacy and Pharmacology·Pui Khee YapDinesh Kumar Chellappan
Nov 26, 2015·Current Opinion in HIV and AIDS·Gus CairnsJean-Michel Molina
Mar 15, 2019·HIV Medicine·Michael BradyIngrid Young
Aug 14, 2019·Journal of the International AIDS Society·Blythe AdamsonDobromir Dimitrov
Oct 16, 2019·Journal of the International AIDS Society·Hanne Ml ZimmermannUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Consortium (H-TEAM)
Dec 11, 2019·International Journal of Environmental Research and Public Health·Dan WuXiaoni Zhong
Oct 27, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Koh Jun OngOwen Noel Gill
Apr 1, 2018·Journal of the International AIDS Society·Elske HoornenborgUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative
Jan 19, 2021·Sexuality Research & Social Policy : Journal of NSRC : SR & SP·Kathryn MacapagalGeorge J Greene
May 12, 2021·Journal of the International AIDS Society·Vita W JongenUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination Amsterdam (H-TEAM) Initiative
Jul 17, 2021·AIDS·Albert Jan van HoekUNKNOWN Amsterdam PrEP Project Team in the HIV Transmission Elimination Amsterdam (H-TEAM) Initiative

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