Cost-Effectiveness of Osimertinib for EGFR Mutation-Positive Non-Small Cell Lung Cancer after Progression following First-Line EGFR TKI Therapy

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Bin WuQiang Zhang

Abstract

The aim of this study was to investigate the cost-effectiveness of osimertinib for the treatment of advanced NSCLC with an EGFR T790M mutation after the failure of first-line EGFR tyrosine kinase inhibitor (TKI) therapy. A mathematical model was established by combining a decision tree and the Markov approach to project the cost-effectiveness of osimertinib versus standard chemotherapy for the treatment of patients who harbor an EGFR T790M mutation and have disease progression after first-line EGFR TKI therapy with or without metastases to the central nervous system. The clinical and outcome data were derived from randomized clinical trials and published reports. The health outcome data included quality-adjusted life-years (QALY). The cost data were estimated from the perspectives of the payer in the United States and the health care system in the People's Republic of China. All costs and incremental cost-effectiveness ratios (ICERs) were presented in 2017 U.S. dollars. Sensitivity and scenario analyses with three different settings of T790M mutation testing were performed. Compared with chemotherapy, molecular testing in plasma and tissue followed by osimertinib treatment yielded an additional 0.359 and 0.313 QALYs in the enti...Continue Reading

Citations

Jun 6, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Alain Vergnenègre, Christos Chouaïd
May 19, 2020·Journal of Comparative Effectiveness Research·Hongfu CaiMaobai Liu
Jun 12, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Osama M Al-Quteimat, Amer M Amer
Aug 25, 2020·The Journal of Applied Laboratory Medicine·Wai Kei Jacky Lam
Sep 5, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Vera Hirsh, Jaspal Singh
Sep 4, 2019·Journal of Comparative Effectiveness Research·Javier Aguilar-SerraJulio Cortijo
Dec 19, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Misako NagasakaSai-Hong Ignatius Ou
Aug 27, 2021·Journal of Cancer Research and Clinical Oncology·Yung-Hung LuoPing Yang
Oct 5, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·J Aguilar-SerraJ Cortijo
Dec 1, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Shahin NargesiNajmeh Moradi

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