Cost-effectiveness of osteoporosis screening and treatment with hormone replacement therapy, raloxifene, or alendronate

Medical Decision Making : an International Journal of the Society for Medical Decision Making
Lee R MobleyJaya K Rao

Abstract

Recent information about osteoporosis treatments and their nonfracture side effects suggests the need for a new cost-effectiveness analysis. The authors estimate the cost effectiveness of screening women for osteoporosis at age 65 and treating those who screen positive with hormone replacement therapy (HRT), raloxifene, or alendronate. A Markov model of osteoporosis disease progression simulates costs and outcomes of women aged 65 years. Incremental cost effectiveness ratios of screen-and-treat strategies are calculated relative to a no-screen, no-treat (NST) strategy. Disease progression parameters are derived from clinical trials; cost and quality-of-life parameters are based on review of cost databases and cost-effectiveness studies. Women are screened using dual-energy x-ray absorptiometry, and women screening positive are treated with HRT, raloxifene, or alendronate. Screening and treatment with HRT increase costs and lower quality-adjusted life years (QALYs; relative to the NST strategy). The only scenario (of several) in the sensitivity analysis in which HRT increases QALYs is when it is assumed that there are no drug-related (nonfracture) health effects. Raloxifene increases costs and QALYs; its cost-effectiveness ratio...Continue Reading

References

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C CooperL J Melton
May 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A C LookerR L Lindsay
Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M RossiniS Adami
Jan 1, 1994·Epidemiology·J A BaronT Tosteson
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N F RayL J Melton
Apr 21, 1999·Journal of Clinical Epidemiology·J A BarrettM L Beach
Nov 14, 2000·Archives of Internal Medicine·G de LissovoyS V Sorensen
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·D M BlackUNKNOWN Fracture Intervention Trial
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Pierre D DelmasUNKNOWN Mulitple Outcomes of Raloxifene Evaluation Investigators
Sep 17, 2002·Annals of Internal Medicine·UNKNOWN U.S. Preventive Services Task Force
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Jul 30, 2003·Archives of Internal Medicine·Peter A UbelA Mark Fendrick

❮ Previous
Next ❯

Citations

Oct 8, 2008·Archives of General Psychiatry·Gary A ZarkinUNKNOWN COMBINE Cost-Effectiveness Research Group
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisD Torgerson
Feb 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J T SchousboeUNKNOWN Osteoporotic Fractures in Men (MrOS) and Study of Osteoporotic Fractures (SOF) Research Groups
Jan 1, 2013·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Björn StollenwerkUwe Siebert
Aug 15, 2009·Menopause : the Journal of the North American Menopause Society·Weng-Foung HuangChia-Rung Tsai
Mar 13, 2009·Southern Medical Journal·Amy H WarrinerJeffrey R Curtis
Apr 19, 2007·BMC Women's Health·Eric S MeadowsJoseph A Johnston
Jun 21, 2011·Applied Health Economics and Health Policy·Dirk Mueller, Afschin Gandjour
Jun 11, 2011·Pathology Research International·André BarkhordarianFrancesco Chiappelli
Dec 8, 2011·Annals of Internal Medicine·Smita NayakSusan L Greenspan
Oct 25, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L SiA J Palmer
Feb 12, 2009·Journal of the American Geriatrics Society·Kouta ItoMary E Charlson
Apr 28, 2007·Cancer·Wendy Y ChenGraham A Colditz
Jan 9, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L SiA J Palmer
Jul 10, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jomkwan YothasamutYot Teerawattananon
Feb 1, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Pritaporn KingkaewYot Teerawattananon
Jul 16, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Afschin Gandjour, Eva-Julia Weyler
Mar 22, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Dirk MüllerAfschin Gandjour
Oct 16, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M YoshimuraT Takiguchi
Apr 6, 2007·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Mark Helfand, Lauren Saxton
Nov 14, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Eric S MeadowsJoseph A Johnston
Jun 21, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·François-Emery CottéGérard De Pouvourville
May 10, 2017·BMC Health Services Research·Louiza S VelentzisKaren Canfell
May 28, 2019·Health Economics Review·Helena ChristellThomas Davidson
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·Lídia Sànchez-Riera, Nicholas Wilson

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