Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach

The Journal of Antimicrobial Chemotherapy
A Vargas-PalaciosJ Minton

Abstract

In the UK, patients who require intravenous antimicrobial (IVA) treatment may receive this in the community through outpatient parenteral antimicrobial therapy (OPAT) services. Services include: IVA administration at a hospital outpatient clinic (HO); IVA administration at home by a general nurse (GN) or a specialist nurse (SN); or patient self-administered (SA) IVA administration following training. There is uncertainty regarding which OPAT services represent value for money; this study aimed to estimate their cost-effectiveness. A cost-effectiveness decision-analytic model was developed using a simulation technique utilizing data from hospital records and a systematic review of the literature. The model estimates cost per QALY gained from the National Health Service (NHS) perspective for short- and long-term treatment of infections and service combinations across these. In short-term treatments, HO was estimated as the most effective (0.7239 QALYs), but at the highest cost (£973). SN was the least costly (£710), producing 0.7228 QALYs. The combination between SN and HO was estimated to produce 0.7235 QALYs at a cost of £841. For long-term treatments, SN was the most effective (0.677 QALYs), costing £2379, while SA was the lea...Continue Reading

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Citations

Jun 13, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gregory M SchrankMary T LaSalvia
Oct 27, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Eliane Molina PsaltikidisMariângela Ribeiro Resende
Nov 22, 2018·The Journal of Antimicrobial Chemotherapy·Jonathan UnderwoodGabriele Pollara

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