Cost-effectiveness of pharmaceutical-based pandemic influenza mitigation strategies.

Emerging Infectious Diseases
Anthony T NewallC Raina Macintyre

Abstract

We used a hybrid transmission and economic model to evaluate the relative merits of stockpiling antiviral drugs and vaccine for pandemic influenza mitigation. In the absence of any intervention, our base-case assumptions generated a population clinical attack rate of 31.1%. For at least some parameter values, population prepandemic vaccination strategies were effective at containing an outbreak of pandemic influenza until the arrival of a matched vaccine. Because of the uncertain nature of many parameters, we used a probabilistic approach to determine the most cost-effective strategies. At a willingness to pay of >A$24,000 per life-year saved, more than half the simulations showed that a prepandemic vaccination program combined with antiviral treatment was cost-effective in Australia.

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Citations

Jul 14, 2012·PharmacoEconomics·Anthony T NewallPhilippe Beutels
Jun 3, 2014·BMC Infectious Diseases·Nilimesh HalderGeorge J Milne
Dec 6, 2016·American Journal of Infection Control·Mark N AbramovichEric S Toner
Sep 27, 2013·Influenza and Other Respiratory Viruses·Naiyana PraditsitthikornYot Teerawattananon
Aug 22, 2018·Scientific Reports·Jiangzhuo ChenMadhav Marathe

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