Cost-effectiveness of potential infant vaccination against respiratory syncytial virus infection in The Netherlands

Vaccine
M J MeijboomM J Postma

Abstract

Respiratory syncytial virus (RSV) infection is one of the major causes of respiratory illness in infants, infecting virtually every child before the age of 2 years. Currently, several Phase 1 trials with RSV vaccines in infants are ongoing or have been completed. As yet, no efficacy estimates are available for these vaccine candidates. Nevertheless, cost-effectiveness estimates might be informative to enable preliminary positioning of an RSV vaccine. A decision analysis model was developed in which a Dutch birth cohort was followed for 12 months. A number of potential vaccination strategies were reviewed such as vaccination at specific ages, a two- or three-dosing scheme and seasonal vaccination versus year-round vaccination. The impact of the assumptions made was explored in various sensitivity analyses, including probabilistic analysis. Outcome measures included the number of GP visits, hospitalizations and deaths, costs, quality-adjusted life years and incremental cost-effectiveness ratios (ICERs). Currently, without vaccination, an annual number of 28,738 of RSV-related GP visits, 1623 hospitalizations, and 4.5 deaths are estimated in children in the age of 0-1 year. The total annual cost to society of RSV in the non-vaccin...Continue Reading

References

Apr 1, 1991·The Journal of Infectious Diseases·C B HallK C Schnabel
Dec 16, 1998·The Pediatric Infectious Disease Journal·K KristensenS Poulsen
May 8, 1995·Journal of Health Economics·M A KoopmanschapL van Roijen
Sep 15, 1999·Lancet·E A Simoes
Feb 27, 2001·The Pediatric Infectious Disease Journal·C J MiedemaJ L Kimpen
Aug 25, 2001·Mathematical Biosciences·A WeberP Milligan
Sep 20, 2001·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J A WeiglH J Schmitt
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Jan 18, 2003·Paediatric Respiratory Reviews·L BontJ L Kimpen
May 8, 2004·The Pediatric Infectious Disease Journal·Louis BontJan L L Kimpen
Jun 15, 2004·The Pediatric Infectious Disease Journal·Edwin RietveldEwout W Steyerberg
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Jun 21, 2005·Journal of Epidemiology and Community Health·Douglas M FlemingKenneth W Cross
Oct 13, 2005·The Pediatric Infectious Disease Journal·Malgorzata A Verboon-MaciolekTon M van Loon
Mar 3, 2006·The Pediatric Infectious Disease Journal·Edwin RietveldUNKNOWN RSV Study Group Southwest Netherlands
Aug 24, 2007·The European Respiratory Journal·A G S C JansenE Hak
May 23, 2008·Journal of Clinical Epidemiology·Angelique G S C JansenEelko Hak
Feb 7, 2009·The New England Journal of Medicine·Caroline Breese HallPeter Szilagyi
Jun 9, 2009·The Pediatric Infectious Disease Journal·Marieke M van der ZalmCornelis K van der Ent
Nov 26, 2009·Pediatrics·Florence T BourgeoisKenneth D Mandl
Jan 29, 2010·Health and Quality of Life Outcomes·Jean-Eric TarrideRon Goeree
Apr 21, 2011·PharmacoEconomics·Mark Jit, Marc Brisson

❮ Previous
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Citations

Jun 27, 2014·PloS One·Hannah C MooreGeoffry N Mercer
Jan 28, 2014·Archives of Disease in Childhood·Joanna MurrayMike Sharland
Dec 5, 2015·Expert Review of Vaccines·Simon B DrysdaleAndrew J Pollard
Dec 21, 2012·Expert Review of Vaccines·Mark H RozenbaumMaarten J Postma
May 20, 2017·Vaccines·Robert J SmithGeoffry N Mercer
Oct 20, 2018·Minerva pediatrica·Anna C VittucciAlberto Villani
Apr 15, 2018·European Journal of Pediatrics·Marwa Ghazaly, Simon Nadel
Nov 24, 2017·European Journal of Pediatrics·Maarten O BlankenUNKNOWN Dutch RSV Neonatal Network
Dec 18, 2018·Israel Journal of Health Policy Research·Gary M GinsbergYechiel Schlesinger
Nov 4, 2020·BMC Health Services Research·Jefferson Antonio Buendía, Ranniery Acuña-Cordero
Sep 8, 2021·BMC Infectious Diseases·Eva Díez-GandíaUNKNOWN Study collaborators
Oct 29, 2021·Health Economics Review·Jefferson Antonio BuendíaCarlos E Rodriguez-Martinez

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