Cost effectiveness of respiratory syncytial virus prophylaxis: a critical and systematic review.

PharmacoEconomics
William A PrescottJoseph A Paladino

Abstract

Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization in the US. The economic burden of severe disease is substantial, including hospitalization costs and out-of-pocket expenses. RSV prophylaxis with either RSV immune globulin intravenous (RSV-IGIV) or palivizumab has been shown to be effective in reducing RSV-related hospitalizations. Motavizumab, a new enhanced-potency humanized RSV monoclonal antibody, is presently in clinical trials. RSV-IGIV and palivizumab are associated with high acquisition costs. Cost-effectiveness analyses are therefore of great importance in helping to determine who should receive RSV prophylaxis. Six studies have analysed the cost effectiveness of RSV-IGIV, 14 have analysed the cost effectiveness of palivizumab and five have analysed the cost effectiveness of both agents, two of which directly compared palivizumab with RSV-IGIV. The cost effectiveness of motavizumab has not been studied. Significant variation exists in the modelling used in these analyses. Many studies have examined short-term benefits such as reducing hospitalizations and associated costs, while fewer studies have examined long-term benefits such as QALYs or life-years gained. The payer and society have b...Continue Reading

References

Apr 29, 1998·Archives of Pediatrics & Adolescent Medicine·J M RobbinsG E Schutze
Oct 27, 1999·JAMA : the Journal of the American Medical Association·D K ShayL J Anderson
Oct 19, 2000·Journal of Paediatrics and Child Health·A Numa
Feb 27, 2001·The Pediatric Infectious Disease Journal·C J MiedemaJ L Kimpen
Jun 21, 2001·Pediatric Pulmonology·L L BartonR J Lemen
Oct 26, 2001·The Annals of Pharmacotherapy·L M SchrandA H Mutnick
Jun 22, 2002·The Pediatric Infectious Disease Journal·Diana FariñaEnrique Laffaire
Aug 14, 2002·Journal of Paediatrics and Child Health·A M VogelM Schousboe
Sep 19, 2002·The Pediatric Infectious Disease Journal·Shelah Leader, Kimmie Kohlhase
Oct 4, 2002·Archives of Pediatrics & Adolescent Medicine·Sachin Kamal-BahlJames Campbell
Nov 28, 2002·Archives of Pediatrics & Adolescent Medicine·Theresa I Shireman, Karen S Braman
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Mar 19, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Shelah LeaderDennis L Murray
Mar 21, 2003·European Journal of Pediatrics·Irmgard Roeckl-WiedmannBernd H Belohradsky
Nov 15, 2003·The Journal of Pediatrics·Shelah Leader, Kimmie Kohlhase
Nov 15, 2003·The Journal of Pediatrics·Susan D Horn, Randall J Smout
Nov 15, 2003·The Journal of Pediatrics·Douglas F WillsonRandall J Smout
Dec 5, 2003·Pediatrics·H Cody MeissnerUNKNOWN American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn
Dec 23, 2003·Clinical Pediatrics·Elizabeth A HelmJames C King
Dec 3, 2004·Pediatrics·Laura E Yount, William T Mahle
Jul 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·N D EmbletonM C Mckean
May 23, 2006·Journal of Paediatrics and Child Health·Carole A ReeveFleur Francis
Oct 5, 2006·Archives of Pediatrics & Adolescent Medicine·Nahed O ElhassanAndrew W Dick
Dec 5, 2006·Pediatrics·Andrea J PelletierCarlos A Camargo
Jun 26, 2007·The Journal of Pediatrics·Eric A F SimoesUNKNOWN Palivizumab Long-Term Respiratory Outcomes Study Group
Sep 29, 2007·Clinical Pediatrics·Julie GoodingRobin Lacroix
Jun 4, 2008·The Pediatric Infectious Disease Journal·Susana P RodríguezGabriela Bauer
Dec 5, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael Forbes
Dec 5, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Paul Checchia

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Citations

Nov 17, 2010·World Journal of Pediatrics : WJP·Jia Hu, Joan L Robinson
Apr 14, 2011·The Pediatric Infectious Disease Journal·Gayle Fischer Langley, Larry J Anderson
Nov 17, 2010·American Journal of Respiratory and Critical Care Medicine·Michael Boeckh, Janet A Englund
Nov 13, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Julia M HussmanKrista L Lanctôt
Jul 12, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsin ChiFu-Yuan Huang
Jun 4, 2013·Current Opinion in Virology·Christine A ShawPhilip R Dormitzer
Apr 9, 2011·New Biotechnology·Jody D Berry, Ryan G Gaudet
Nov 10, 2012·Pediatric Pulmonology·Almut G WintersteinPamela Schuler
Apr 17, 2015·BioMed Research International·José Eduardo VargasRenato Tetelbom Stein
Aug 11, 2011·Korean journal of pediatrics·Nam Kyun Kim, Jae Young Choi
Aug 9, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Giuseppe A Marraro, Claudio Spada
Oct 8, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A-F DureauM Leone
Feb 8, 2018·Journal of Clinical Pharmacology·Yan XinJeffrey A Silverman
Nov 2, 2014·BMC Infectious Diseases·Javier Díez-DomingoPablo Lázaro
Oct 19, 2019·Influenza and Other Respiratory Viruses·David HodgsonRichard Pebody
May 10, 2017·Open Forum Infectious Diseases·Susan T PastulaJon Fryzek
Apr 6, 2012·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·William A Prescott, David J Hutchinson
Apr 1, 2018·NeoReviews·Wannasiri LapcharoensapDmitry Dukhovny
Jun 10, 2016·Clinical Microbiology Reviews·Erik De Clercq, Guangdi Li
Sep 10, 2021·Human Vaccines & Immunotherapeutics·Ahinsa Gunatilaka, Michelle L Giles

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