Cost-effectiveness of Sativex in multiple sclerosis spasticity: new data and application to Italy

Expert Review of Pharmacoeconomics & Outcomes Research
John SlofCarlos Vila

Abstract

Multiple sclerosis (MS) is a chronic progressive disease that carries a high socioeconomic burden. Spasticity (rigidity and spasms) is common in MS and contributes to MS-related disability. This study aims to evaluate the cost-effectiveness of Sativex(®) (9-delta-tetrahydrocannabinol plus cannabidiol oromucosal spray) when used as add-on therapy for management of resistant MS-related spasticity in the context of the Italian healthcare system. A previously published Markov model-based analysis for the German and Spanish context was replicated, adapting it to the Italian setting. Model parameters were updated to reflect recent findings about MS-related spasticity and use of Sativex in daily clinical practice. The base case incremental cost-effectiveness ratio for Sativex use in Italy over a 5-year period was estimated to be €4968 per quality-adjusted life-year gained (year of costing: 2013). Sativex remained an efficient option in the Italian healthcare context - below the commonly accepted incremental threshold of €30,000 per quality-adjusted life-year gained - when deterministic and probabilistic sensitivity analyses were conducted. Sativex can be regarded as a cost-effective treatment option for patients with MS-related spasti...Continue Reading

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Citations

Jul 15, 2015·Expert Review of Neurotherapeutics·Sven G MeuthKerry L Dechant
Nov 28, 2015·Neurodegenerative Disease Management·Ludwig Kappos, Franz Fazekas
Jan 12, 2016·Expert Review of Pharmacoeconomics & Outcomes Research·Adrien Gras, Julie Broughton
Nov 17, 2017·Neurodegenerative Disease Management·Ralf Linker
Apr 5, 2019·Cannabis and Cannabinoid Research·Griffin A TyreeDavid J Grelotti
Apr 3, 2021·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Christopher VannabouathongMohit Bhandari
Apr 22, 2021·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Mark OppeJuan M Ramos-Goñi

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