Cost-Effectiveness of Saxagliptin Compared With Glibenclamide as a Second-Line Therapy Added to Metformin for Type 2 Diabetes Mellitus in Ethiopia.

MDM Policy & Practice
Mengistu BekeleAlemayehu Hailu

Abstract

Background. Metformin is a widely accepted first-line pharmacotherapy for patients with type 2 diabetes mellitus (T2DM). Treatment of T2DM with glibenclamide, saxagliptin, or one of the other second-line treatment agents is recommended when the first-line treatment (metformin) cannot control the disease. However, there is little evidence on the additional cost and cost-effectiveness of adding second-line drugs. Therefore, this study aimed to estimate the cost-effectiveness of saxagliptin and glibenclamide as second-line therapies added to metformin compared with metformin only in T2DM in Ethiopia. Methods. This cost-effectiveness study was conducted in Ethiopia using a mix of primary data on cost and best available data from the literature on the effectiveness. We measured the interventions' cost from the providers' perspective in 2019 US dollars. We developed a Markov model for T2DM disease progression with five health states using TreeAge Pro 2020 software. Disability-adjusted life year (DALY) was the health outcome used in this study, and we calculated the incremental cost-effectiveness ratio (ICER) per DALY averted. Furthermore, one-way and probabilistic sensitivity analysis were performed. Results. The annual unit cost per...Continue Reading

References

Oct 1, 1993·Medical Decision Making : an International Journal of the Society for Medical Decision Making·F A Sonnenberg, J R Beck
Nov 3, 1998·Journal of General Internal Medicine·D K Owens
Dec 23, 2003·Cost Effectiveness and Resource Allocation : C/E·Raymond HutubessyTessa Tan-Torres Edejer
Apr 2, 2009·BMC International Health and Human Rights·Joses M KirigiaSaidou P Barry
Nov 11, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Michael DrummondJohan Severens
Dec 31, 2009·Diabetes Care·Jonathan B BrownGregory A Nichols
Jul 28, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew Briggs
Oct 5, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Scott KlarenbachEhud Ur
Oct 18, 2011·Primary Care Diabetes·Ola GranströmMartin Henriksson
Jan 1, 2011·Clinical Medicine Insights. Endocrinology and Diabetes·Jay ShubrookFrank Schwartz
Apr 30, 2013·Health Economics Review·Jorge F ElgartJuan J Gagliardino
Feb 1, 2014·BMC Public Health·Solomon Mekonnen AbebeAbebayehu Assefa
Jan 13, 2016·Nigerian Journal of Clinical Practice·I L OkoronkwoP N Iheanacho
Jan 23, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Alison HayesPhilip Clarke
Jan 25, 2017·Journal of Pharmaceutical Policy and Practice·M EwenR Laing
Dec 9, 2017·Nature Reviews. Endocrinology·Yan ZhengFrank B Hu
Mar 23, 2019·BMJ Global Health·Corrina MoucheraudVeronika J Wirtz
Nov 28, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Viswanathan MohanJean C Mbanya

❮ Previous
Next ❯

Software Mentioned

TreeAge Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.