PMID: 2119161Oct 15, 1990Paper

Cost effectiveness of screening perimenopausal white women for osteoporosis: bone densitometry and hormone replacement therapy

Annals of Internal Medicine
A N TostesonM C Weinstein

Abstract

Bone mass measurement at menopause to identify and selectively prescribe hormone replacement therapy for women at high risk for fractures has seen limited clinical use. We used epidemiologic, clinical, and economic data in a decision-analytic model to compare the following clinical strategies for perimenopausal, asymptomatic, white women with intact uteri: no intervention; bone mineral density measurement followed by selective, long-term (15-year) estrogen-progestin therapy in women with low bone mass; and unselective, universal hormone replacement therapy. Life expectancy and direct medical cost per patient were estimated for each strategy. Strategies for screening and treating women with perimenopausal bone mineral density less than 0.9 g/cm2 or less than 1.0 g/cm2 would cost $11,700 or $22,100, respectively, per year of additional life gained. If the cost of screening is less than $84, then resource savings from hip fractures prevented would be more than the cost of screening and treatment. Universal treatment without screening would prevent additional fatal fractures but would expose many more women to the adverse effects of hormone replacement therapy and would cost an additional $349,000 per year of life gained compared w...Continue Reading

Citations

Nov 18, 2000·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·A CranneyP Tugwell
Nov 18, 1997·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·H S RuchlinJ P Allegrante
Apr 1, 1993·Health Economics·J Cairns, P Shackley
Jul 1, 1994·Journal of Clinical Pharmacology·A N Tosteson
Oct 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J MeltonB L Riggs
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C J Rosen
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R L PrinceM Smith
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H Mallmin, S Ljunghall
Mar 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D ThiébaudC Gobelet
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Ankjaer-Jensen, O Johnell
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M Lau
Jul 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A P Clark, J A Schuttinga
Jan 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A RandellJ A Eisman
Jan 13, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·David J VannessL Joseph Melton
Jun 28, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Rachael L FleurenceDavid J Torgerson
Nov 10, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N ZethraeusB Jönsson
Aug 18, 1997·The American Journal of Medicine·O Johnell
Jan 1, 1996·Clinical Therapeutics·T A AbbottS Wallach
Oct 31, 2002·American Journal of Preventive Medicine·Peter J Neumann, Bat Sheva Levine
Mar 1, 1997·Endocrinology and Metabolism Clinics of North America·T N Taylor, E A Chrischilles
Mar 1, 1997·Endocrinology and Metabolism Clinics of North America·N R PoweP W Ladenson
Aug 1, 1997·Trends in Endocrinology and Metabolism : TEM·D J TorgersonD M Reid
Sep 19, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·K BrixenL Mosekilde
Sep 9, 2000·The New England Journal of Medicine·G L Eastwood
Apr 4, 2000·Journal of Women's Health & Gender-based Medicine·A N TostesonL J Melton
Nov 26, 1999·Clinical Obstetrics and Gynecology·T Pejovic, D L Olive
Nov 14, 2001·The Journal of Trauma·E OlschewskiJ N Powell
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·N ZethraeusR T Strand
Oct 1, 1995·Annals of the Rheumatic Diseases·G G Riario-SforzaM Fumagalli
Mar 6, 1993·BMJ : British Medical Journal·A E Raffle
Aug 3, 2002·BMJ : British Medical Journal·Toby B Gosden, David J Torgerson
Feb 8, 1992·Quality in Health Care : QHC·T A SheldonA F Long
Jan 1, 1995·Annual Review of Medicine·K M PrestwoodL G Raisz
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Suarez-AlmazorP Davis
Jan 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J MeltonB L Riggs

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