Cost-effectiveness of sex-neutral HPV-vaccination in Sweden, accounting for herd-immunity and sexual behaviour

Vaccine
Ellen WolffAdam Roth

Abstract

The aim was to assess cost-effectiveness of expanding the Swedish HPV-vaccination program to include preadolescent boys, by comparing health-effects and costs of HPV-related disease, with a sex-neutral vaccination program versus only vaccinating girls. We used a dynamic compartmental model to simulate the burden of HPV16/18-related disease in Sweden, accounting for indirect effects of vaccination through herd-immunity. The model accounted for sexual behaviour, such as age preferences and men who have sex with men. The main outcome was number of individuals with HPV-related cancers (cervical, genital, anal and oropharyngeal cancer) and cervical intraepithelial neoplasia (CIN). Costs included in the analysis were those incurred when treating HPV-related cancer and CIN, production losses during sick-leave, and acquisition and administration of vaccine. Health effects were measured as quality-adjusted life years (QALY). The time horizon was set to 100 years, and both effects and costs were discounted by 3% annually. Health effects and costs were accumulated over the time horizon and used to create an incremental cost-effectiveness ratio. A sex-neutral vaccination program would reduce HPV-related cancer and CIN, both due to direct e...Continue Reading

Citations

Aug 26, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Lisa CaulleyJennifer J Shin
Jul 23, 2020·PharmacoEconomics·David D KimPeter J Neumann
Jul 31, 2019·JNCI Cancer Spectrum·Venetia QendriJohannes Berkhof
Jun 25, 2021·Journal of Epidemiology and Community Health·Renata LinertováMontserrat Carmona-Rodríguez

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