Cost-effectiveness of sigmoid resection with primary anastomosis or end colostomy for perforated diverticulitis: an analysis of the randomized Ladies trial.

The British Journal of Surgery
Daniël Pv LambrichtsJohan F Lange

Abstract

Several studies have been published favouring sigmoidectomy with primary anastomosis over Hartmann's procedure for perforated diverticulitis with purulent or faecal peritonitis (Hinchey grade III or IV), but cost-related outcomes were rarely reported. The present study aimed to evaluate costs and cost-effectiveness within the DIVA arm of the Ladies trial. This was a cost-effectiveness analysis of the DIVA arm of the multicentre randomized Ladies trial, comparing primary anastomosis over Hartmann's procedure for Hinchey grade III or IV diverticulitis. During 12-month follow-up, data on resource use, indirect costs (Short Form Health and Labour Questionnaire) and quality of life (EuroQol Five Dimensions) were collected prospectively, and analysed according to the modified intention-to-treat principle. Main outcomes were incremental cost-effectiveness (ICER) and cost-utility (ICUR) ratios, expressed as the ratio of incremental costs and the incremental probability of being stoma-free or incremental quality-adjusted life-years respectively. Overall, 130 patients were included, of whom 64 were allocated to primary anastomosis (46 and 18 with Hinchey III and IV disease respectively) and 66 to Hartmann's procedure (46 and 20 respectiv...Continue Reading

References

Jan 1, 1996·International Journal of Technology Assessment in Health Care·L van RoijenF F Rutten
Dec 13, 2000·Statistics in Medicine·J A Barber, S G Thompson
Jul 20, 2002·Diseases of the Colon and Rectum·Jyrki MäkeläSeppo Laitinen
May 30, 2008·The British Journal of Surgery·C R MorrisA R Hart
Feb 13, 2009·Annals of Surgery·David A EtzioniAndreas M Kaiser
Apr 8, 2011·World Journal of Gastroenterology : WJG·Geoffrey C NguyenNitasha Anand
Feb 1, 2012·The British Journal of Surgery·A ChabokUNKNOWN AVOD Study Group
Mar 27, 2013·PharmacoEconomics·Don HusereauElizabeth Loder
May 8, 2014·International Journal of Colorectal Disease·Aras Jamal TalabaniTom-Harald Edna
Nov 8, 2014·Diseases of the Colon and Rectum·Debbie LiAvery B Nathens
Sep 30, 2015·The American Journal of Gastroenterology·Adil E BharuchaAlan R Zinsmeister
Oct 16, 2015·Critical Care Medicine·Stefan SchandelmaierMatthias Briel
Oct 1, 2016·The British Journal of Surgery·L DanielsUNKNOWN Dutch Diverticular Disease (3D) Collaborative Study Group
Apr 26, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M GachabayovR Bergamaschi
Sep 10, 2018·Techniques in Coloproctology·Gian Andrea BindaB Annibale
Oct 20, 2018·The British Journal of Surgery·C T AquinaF J Fleming
Feb 28, 2019·The British Journal of Surgery·S Biondo
Feb 28, 2019·The British Journal of Surgery·D P V LambrichtsJ F Lange
Apr 24, 2019·The British Journal of Surgery·F SköldbergO Olén
Jul 20, 2019·World Journal of Emergency Surgery : WJES·Juha MaliVille Sallinen
Aug 10, 2019·Techniques in Coloproctology·J B BroadM J Connolly

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage

Clinical Trials Mentioned

NCT01317485

Software Mentioned

R
SPSS®

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.