Cost-effectiveness of somatropin for the treatment of short children born small for gestational age

Clinical Therapeutics
Torsten ChristensenRachael Baker-Searle

Abstract

Short children born small for gestational age (SGA) may be at increased risk for long-term morbidity and reduced health-related quality of life (HRQoL) due to their short stature. Normalization of height in childhood and adolescence is possible in such children via the use of the recombinant human growth hormone somatropin. The aim of this study was to determine whether somatropin was a cost-effective treatment option in short children born SGA. A decision analytic model was constructed to calculate the cost-effectiveness of somatropin treatment versus no treatment over the lifetime of a short individual born SGA, from the perspective of the UK National Health Service (NHS). The model was based on patient-level data from a multicenter, double-blind, randomized controlled trial that reported the effects of somatropin on final (adult) height in short children born SGA. Health care resource and drug costs associated with each of the treatment arms were considered, and published utility scores were used to calculate improvement in HRQoL. The model calculated incremental costs and incremental quality-adjusted life-years (QALYs) associated with somatropin treatment compared with no treatment. Cost-effectiveness was expressed as incre...Continue Reading

References

Jun 1, 1987·Psychological Reports·W E Hensley, R Cooper
Aug 1, 1995·Pediatric Research·A C Hokken-KoelegaS L Drop
Sep 8, 2000·PharmacoEconomics·A H Briggs
Aug 2, 2002·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew H BriggsBernie J O'Brien
Jul 24, 2004·BMJ : British Medical Journal·Michael D Rawlins, Anthony J Culyer
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Yvonne K van ParerenAnita C S Hokken-Koelega
Nov 13, 2004·Hormone Research·Robert H Lustig
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eyal SheinerMoshe Mazor
Aug 12, 2005·The Journal of Urology·Kourosh AfsharNancy Vaneyke
Oct 6, 2005·Hormone Research·Ellen M N BanninkAnita C S Hokken-Koelega
Feb 10, 2006·Current Medical Research and Opinion·Ashish V JoshiMason W Russell
Jun 21, 2007·Health & Social Care in the Community·Karen JonesAndrew Bebbington
Sep 5, 2007·Archives of Disease in Childhood·R R KapoorC L Acerini

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Citations

Nov 14, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Neuza SilvaUNKNOWN QoLISSY Group
Jun 28, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nick AdlardEmma Frew
Feb 3, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eric CarlsonAbayomi Ogundele
Jun 30, 2012·The Journal of Clinical Endocrinology and Metabolism·Joël CosteJean-Claude Carel
Dec 15, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Omar Ali, David Wyatt

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