Cost Effectiveness of Sucroferric Oxyhydroxide Compared with Sevelamer Carbonate in the Treatment of Hyperphosphataemia in Patients Receiving Dialysis, from the Perspective of the National Health Service in Scotland

PharmacoEconomics
Florian S GutzwillerM Schwenkglenks

Abstract

Hyperphosphataemia is common and harmful in patients receiving dialysis. Treatment options include noncalcium-based phosphate binders such as sevelamer carbonate (SC) and sucroferric oxyhydroxide (PA21). The aim of this study was to determine the health economic impact of PA21-based strategies compared with SC-based strategies, from the perspective of the Scottish National Health Service (NHS). A Markov model was constructed based on data from a randomised clinical trial comparing PA21 and SC. Model input parameters were derived from published literature, national statistics and unpublished sources. Costs (price year 2012) and effects were discounted at 3.5 %. Analysis with a lifelong time horizon yielded the incremental cost-effectiveness ratio (ICER), expressed as cost or savings per quality-adjusted life-year (QALY) gained or forgone. Deterministic and probabilistic sensitivity analysis was performed to explore uncertainties around assumptions and model input parameters. In the base-case analysis, phosphorus reductions for PA21 and SC were 1.93 and 1.95 mg/dL. Average undiscounted survival was estimated to be 7.61 years per patient in both strategies. PA21 patients accrued less QALYs (2.826) than SC patients (2.835), partial...Continue Reading

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Citations

Feb 3, 2018·PharmacoEconomics·Björn StollenwerkVasily Belozeroff
Nov 27, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·J Emilio Sanchez-AlvarezCarmen Rodríguez Suárez
Mar 8, 2021·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Kamolpat ChaiyakittisoponAmmarin Thakkinstian

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