PMID: 9161657May 1, 1997Paper

Cost-effectiveness of thrombolytic therapy for acute myocardial infarction

The Annals of Pharmacotherapy
P A CastilloB J Gersh

Abstract

To estimate the cost-effectiveness of thrombolytic therapy versus no thrombolytic therapy for patients following acute myocardial infarction, focusing on the impact of time to treatment on outcome. A decision model was developed to assess the benefits, risks, and costs associated with thrombolytic therapy for treatment of acute myocardial infarction compared with standard nonthrombolytic therapy. The model used pooled data from a recent study of nine large randomized, controlled clinical trials and 12-month outcome data from a recently published meta-analysis of thrombolytic therapy trial data. Outcomes were expressed in terms of survival to hospital discharge and survival to 1 year after discharge. The risks of treatment that led to death, morbidity, or added costs were estimated. The model determined excess and marginal costs per death averted to hospital discharge and at 1 year. Results were also estimated in terms of cost per year of life saved. Sensitivity analyses included variations in time to treatment and drug cost. The marginal cost of thrombolytic therapy per death averted at 1 year was $222,344, or $14,438 per year of life saved. For patients treated within 6 hours of acute myocardial infarction, the marginal cost p...Continue Reading

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Citations

Dec 1, 1999·Critical Care Medicine·D L Bowton
Jul 22, 2005·Medical Care·Michael B RothbergDavid N Rose
Apr 4, 2002·Journal of General Internal Medicine·Joel F WallaceJoshua J Ofman
Dec 26, 2006·Health Care Management Science·K CooperJ Raftery
Nov 19, 2003·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Carl Clare, Ian Bullock

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