Cost-effectiveness thresholds: methods for setting and examples from around the world

Expert Review of Pharmacoeconomics & Outcomes Research
André Soares SantosCristina Mariano Ruas

Abstract

Cost-effectiveness thresholds (CETs) are used to judge if an intervention represents sufficient value for money to merit adoption in healthcare systems. The study was motivated by the Brazilian context of HTA, where meetings are being conducted to decide on the definition of a threshold. An electronic search was conducted on Medline (via PubMed), Lilacs (via BVS) and ScienceDirect followed by a complementary search of references of included studies, Google Scholar and conference abstracts. Cost-effectiveness thresholds are usually calculated through three different approaches: the willingness-to-pay, representative of welfare economics; the precedent method, based on the value of an already funded technology; and the opportunity cost method, which links the threshold to the volume of health displaced. An explicit threshold has never been formally adopted in most places. Some countries have defined thresholds, with some flexibility to consider other factors. An implicit threshold could be determined by research of funded cases. CETs have had an important role as a 'bridging concept' between the world of academic research and the 'real world' of healthcare prioritization. The definition of a cost-effectiveness threshold is paramo...Continue Reading

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Citations

May 18, 2019·Future Healthcare Journal·Terry YoungSada Soorapanth
Oct 15, 2019·Expert Review of Pharmacoeconomics & Outcomes Research·Sun-Kyeong ParkChanhyun Park
Feb 6, 2020·Cadernos de saúde pública·João Paulo Vilela RodriguesLeonardo Régis Leira Pereira
Jun 15, 2019·Journal of Medical Economics·Lieven Annemans
Sep 22, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Jessica OchalekKimberly M Thompson
Feb 13, 2021·Gates Open Research·Y-Ling ChiAlexander Winch
Apr 13, 2021·International Journal of Technology Assessment in Health Care·Abeer A Al-Rabayah, Saad M Jaddoua
Jan 19, 2022·Applied Health Economics and Health Policy·Sándor KovácsAntal Zemplényi

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