Cost-Effectiveness/Cost-Benefit Analysis of Newborn Screening for Severe Combined Immune Deficiency in Washington State

The Journal of Pediatrics
Yao DingScott D Grosse

Abstract

To evaluate the expected cost-effectiveness and net benefit of the recent implementation of newborn screening (NBS) for severe combined immunodeficiency (SCID) in Washington State. We constructed a decision analysis model to estimate the costs and benefits of NBS in an annual birth cohort of 86 600 infants based on projections of avoided infant deaths. Point estimates and ranges for input variables, including the birth prevalence of SCID, proportion detected asymptomatically without screening through family history, screening test characteristics, survival rates, and costs of screening, diagnosis, and treatment were derived from published estimates, expert opinion, and the Washington NBS program. We estimated treatment costs stratified by age of identification and SCID type (with or without adenosine deaminase deficiency). Economic benefit was estimated using values of $4.2 and $9.0 million per death averted. We performed sensitivity analyses to evaluate the influence of key variables on the incremental cost-effectiveness ratio (ICER) of net direct cost per life-year saved. Our model predicts an additional 1.19 newborn infants with SCID detected preclinically through screening, in addition to those who would have been detected ...Continue Reading

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Citations

Jul 29, 2017·Journal of Paediatrics and Child Health·Melissa NormanPaul Gray
Jan 30, 2018·International Journal of Neonatal Screening·Scott D GrosseMatthew E Oster
May 12, 2018·Current Allergy and Asthma Reports·John Routes, James Verbsky
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Feb 26, 2019·European Journal of Pediatrics·Catharina P B Van der PloegM Elske Van den Akker-van Marle
Mar 21, 2020·Frontiers in Immunology·Ilya KorsunskiyDaniel Munblit
Dec 12, 2018·International Journal of Neonatal Screening·Maartje BlomPeter C J I Schielen
Aug 30, 2019·International Journal of Neonatal Screening·Alice BesseyRuth Wong
Nov 27, 2020·International Journal of Neonatal Screening·Pasquale CacciatoreM Elske van den Akker-van Marle
Sep 30, 2019·Immunology and Allergy Clinics of North America·Hey J ChongJennifer Heimall
Sep 16, 2020·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C ThomasM Audrain
Dec 22, 2017·Pediatrics·Ang XuStephanie R Morain

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