Cost evaluation of gadoxetic acid-enhanced magnetic resonance imaging in the diagnosis of colorectal-cancer metastasis in the liver: Results from the VALUE Trial

European Radiology
C J ZechE Jonas

Abstract

To assess the costs of diagnostic workup and surgery of three strategies for patients with colorectal cancer liver-metastases (CRCLM): gadoxetic-acid-enhanced MRI (Gd-EOB-DTPA-MRI), MRI with extracellular contrast-media (ECCM-MRI) or contrast-enhanced MDCT (CE-MDCT). The within-trial cost evaluation was modelled as a decision-tree to calculate the cost of diagnosis and surgery. The model used clinical outcomes and resource utilization data from a prospective randomized multicentre study. Analyses were performed for the 354-patient safety population from eight participating countries. The diagnostic workup cost using Gd-EOB-DTPA-MRI upfront resulted in savings compared to ECCM-MRI in all countries except Thailand (difference <2 %). Compared to CE-MDCT, initial imaging with Gd-EOB-DTPA-MRI was less costly in all countries except Korea and Spain (differences 4 and 8 %, respectively). Significantly more patients in the Gd-EOB-DTPA-MRI group were eligible for surgery (39.3 % (48/122) vs. 31.0 % (36/116) and 26.7 % (31/116) for ECCM-MRI and CE-MDCT, respectively), allowing more patients to undergo potentially curative surgery, but resulting in higher treatment costs for the strategy starting with Gd-EOB-DTPA-MRI. The benefits of Gd-E...Continue Reading

References

May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Sep 1, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A SjövallT Holm
Dec 23, 2009·Journal of Magnetic Resonance Imaging : JMRI·Irene FlorianiAndrea Giovagnoni
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Olivio F DonatiDominik Weishaupt
Apr 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Brett KnowlesMyrddin Rees
Sep 11, 2012·The Oncologist·René AdamUNKNOWN Jean-Nicolas Vauthey of the EGOSLIM (Expert Group on OncoSurgery management of LIver Metastases) group
Jun 14, 2015·European Radiology·Elmar M MerkleMengsu Zeng

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Citations

Sep 10, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Dong Ho LeeUNKNOWN Korean Society of Abdominal Radiology
Aug 9, 2019·Abdominal Radiology·Christopher L WelleSudhakar K Venkatesh
Nov 18, 2020·Journal of Hepato-biliary-pancreatic Sciences·Masakazu YamamotoTadahiro Takada

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