Cost of treating advanced colorectal cancer: a retrospective comparison of treatment regimens

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P RossD Cunningham

Abstract

Introduction of new agents on to hospital drug formularies requires the demonstration of efficacy, safety and cost advantages. An audit of the total monthly costs of 'Tomudex' (raltitrexed; administered every 3 weeks), a drug recently introduced for the treatment of advanced colorectal cancer, and three 5-fluorouracil-based regimens [5-day daily bolus (Mayo); continuous ambulatory pump; 48-h continuous infusion (De Gramont)] was undertaken. Patient-specific costs associated with fluids, concomitant medication and consumables were largely negligible, but chemotherapy was the main cost driver in the raltitrexed and De Gramont groups. Fixed inpatient costs were highest for the patients receiving the De Gramont regimen which required more impatient stays each month. Total costs (patient-specific plus fixed costs) were lowest in patients on the Mayo regimen (mean 954.03 Pounds; median 659.68 Pounds), followed by patients in the ambulatory pump (mean 1207.61 Pounds; median 749.19 Pounds), raltitrexed [mean 1256.93 Pounds; median 1087.14 Pounds (mean 1117.85 Pounds; median 959.34 Pounds when costs of protocol-driven visits were excluded)], and De Gramont groups (mean 2028.52 Pounds; median 1775.66 Pounds). The pattern of costs varied ...Continue Reading

Citations

Feb 14, 2006·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Samuel LimatMarie-Christine Woronoff-Lemsi
Nov 22, 2007·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Laurence ClercAnne-Marie Bouvier
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Ketevan PachkoriaXiao-Feng Sun
Aug 20, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·R J ThomasJ Garcia-Vargas
Sep 24, 2004·ANZ Journal of Surgery·Dragan DamjanovicMichael P N Findlay
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T J IvesonE Van Cutsem
Apr 6, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C TwelvesUNKNOWN Xeloda Colorectal Cancer Study Group
Oct 29, 2014·Journal of the National Cancer Institute·Dawn L HershmanAlfred I Neugut
Jun 28, 2002·British Journal of Cancer·J P HaleR J Stephens
Apr 23, 2003·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·B Glimelius
Sep 4, 2010·Research in Social & Administrative Pharmacy : RSAP·Dong-Churl SuhSusan Goodin

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