Cost-utility analysis of adjuvant therapies for breast cancer in Iran

International Journal of Technology Assessment in Health Care
P Bastani, Aliasghar Ahmad Kiadaliri

Abstract

The aim of this study was to evaluate the cost-utility of Docetaxel with doxorubicin and cyclophosphamide (TAC) and 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) in node-positive breast cancer patients in the south of Iran. A double blind study was done on a cohort of 100 patients suffering from breast cancer with node-positive over 8 months in the radiotherapy center of Namazi hospital, Shiraz-Iran. Health-related quality of life was assessed using questionnaire (QLQ-C30) from European Organization for Research and Treatment of Cancer (EORTC). QLQ-C30 scale scores were mapped to 15D and EuroQol 5D utilities to measure the quality-adjusted life-years (QALYs).Third party payer point of view was applied to measure and value the cost of treatments. Cost data were extracted from hospital and health insurance organizations. Robustness of the results was checked through a two way sensitivity analysis. TAC was associated with higher deterioration in HRQoL during treatment and higher improvements over 4 months follow-up. On average, the cost of treatment per patient in TAC was 15 times higher than FAC (p < .001). In overall, TAC was resulted in lower QALYs and higher cost over study period. FAC was a dominant option versus TAC in...Continue Reading

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Oct 27, 2010·Medical Oncology·Peivand Bastani, Aliasghar Ahmad Kiadaliri

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Citations

Sep 8, 2015·Health Policy·Shohreh ShahabiRegina Ram
Aug 31, 2016·Breast Cancer Research and Treatment·Virginie NerichBernhard Holzner
Jan 15, 2021·Cost Effectiveness and Resource Allocation : C/E·Reza HashempourAli AkbariSari

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