Cost-utility analysis of once-daily versus twice-daily inhaled corticosteroid dosing for maintenance treatment of asthma in pediatric patients

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Carlos E Rodriguez-MartinezJose A Castro-Rodriguez

Abstract

Suboptimal adherence to inhaled corticosteroids (ICs) is an important cause of poor asthma control in pediatric patients. Among the factors that can be most easily changed for enhancing adherence to ICs is a reduction in the dosing frequency, from twice-daily dosing to once-daily dosing. However, no previous studies have reported an economic evaluation comparing once-daily versus twice-daily IC dosing for pediatric asthma. The aim of this study was to compare the cost-effectiveness of once-daily versus twice-daily IC dosing for maintenance treatment of asthma in pediatric patients. A Markov-type model was developed in order to estimate costs and health outcomes of a simulated cohort of pediatric patients with persistent asthma treated over a 12-month period. Effectiveness parameters were obtained from a systematic review of the literature. Cost data were obtained from official databases provided by the Colombian Ministry of Health. The main outcome was the variable "quality-adjusted life-years" (QALYs). For the base-case analysis, the model showed that compared with twice-daily dosing, once-daily dosing strategy involved lower costs (US$1529.3 versus $1709.1 average cost per patient over 12 months) and the greatest gain in QALY...Continue Reading

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Citations

Aug 24, 2016·The World Allergy Organization Journal·Elham HossnyPeter Le Souef
Jan 22, 2019·Journal of Medical Economics·Bunchai ChongmelaxmePiyameth Dilokthornsakul
Aug 2, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Carlos E Rodriguez-MartinezJose A Castro-Rodriguez
Oct 2, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Luca Adél HalmaiMary Kilonzo
Jan 14, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Sin Mei KhawNurul Ain Mohd Tahir
Jan 19, 2021·Pediatric Pulmonology·Elida Duenas-MezaCarlos A Torres-Duque
May 29, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño

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