PMID: 9435927Jan 22, 1998Paper

Cost-utility analysis of taxane therapy

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
G C Yee

Abstract

A cost-utility analysis of docetaxel versus paclitaxel in patients with anthracycline-resistant metastatic breast cancer was reviewed. Cost-utility analysis provides estimates of the additional cost of a new therapy per quality-adjusted life-year (QALY) saved or gained. Utility scores measure the strength of a patient's preference for a given health state or outcome. Few studies have evaluated preferences in patients receiving cancer treatment. Since docetaxel may represent an advance in the management of anthracycline-resistant recurrent metastatic breast cancer, a decision-analysis model was developed to evaluate the pharmacoeconomics of this drug versus those of paclitaxel. Although the overall treatment costs of docetaxel were slightly higher than those of paclitaxel, docetaxel was associated with a gain of 0.0905 QALY per patient. This gain in QALYs is equivalent to 33 days of perfect health, which represents a substantial proportion of the life expectancy of one of these patients (typically no longer than nine months). The incremental cost-utility ratio associated with docetaxel therapy was estimated to be $4011 per QALY. Compared with paclitaxel, docetaxel for anthracycline-resistant metastatic breast cancer is within th...Continue Reading

Citations

Feb 24, 2007·Medicinal Research Reviews·Y K AgrawalPathik Brahmkshatriya
Oct 16, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carmen FríasMiguel Ángel Casado
Jan 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Martín-JiménezM Brosa-Riestra
Feb 25, 2009·Expert Opinion on Pharmacotherapy·Zarnie Lwin, Natasha Leighl
Jun 12, 2002·Current Treatment Options in Oncology·J F De los Santos, T A Buchholz
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shanu ModiAndrew Seidman
Feb 2, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Marino

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