Costimulation regulates the kinetics of interleukin-2 response to bacterial superantigens

Immunology
E MurailleO Leo

Abstract

The aim of this study was to investigate the mechanisms by which B7-related costimulatory molecules (CD80, CD86) increase T-cell responsiveness to extracellular ligands. As a model study, the in vitro response of purified splenic CD4+ T cells to a bacterial superantigen, SEB, was characterized. Previous analysis of this experimental model led us to conclude that expression of B7-related molecules is strictly required in order to activate CD4+ T cells in the presence of bacterial superantigens. In the present report, we demonstrate that antigen-presenting cell-derived costimulatory signals regulate the kinetics of interleukin-2 (IL-2) production by SEB-activated splenic CD4+ T cells. Indeed, experiments performed with purified subpopulations of antigen-presenting cells and using B7-transfected cell lines indicated that increased levels of CD80 and/or CD86 cell surface expression is associated with a faster kinetics of IL-2 production in response to SEB. Accordingly, blocking of CD80 or CD86-derived signals by specific monoclonal antibodies led to a slower kinetics of IL-2 production in response to SEB. Thus these data demonstrate that similar strength of signal through the T-cell receptor can lead to immune responses displaying ...Continue Reading

References

Jun 15, 1990·Science·R H Schwartz
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S LinsleyJ A Ledbetter
Apr 1, 1987·European Journal of Immunology·W Müller, P Vandenabeele
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z Razi-WolfH Reiser
Aug 1, 1993·The Journal of Experimental Medicine·N BhardwajR M Steinman

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Citations

Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·S HallezO Leo
Jul 1, 1997·Research in Immunology·S Florquin, L Aaldering
Nov 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline DuaultMary Poupot
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D ScalesD Weissman

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