PMID: 9181469May 1, 1997Paper

Costimulation with ultraviolet B and interleukin-1 alpha dramatically increase tumor necrosis factor-alpha production in human dermal fibroblasts

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
H FujisawaD N Sauder

Abstract

Ultraviolet light, particularly in wavelengths of 290-320 nm (UVB), is known to induce cytokine synthesis in the skin. Cytokines act in a cascade fashion and can have synergistic or antagonistic actions on regulation of other cytokines. In this study, we sought to determine whether cotreatment with UVB and interleukin-1 alpha (IL-1 alpha) induces tumor necrosis factor-alpha (TNF-alpha) production synergistically by human dermal fibroblasts. UVB irradiation (200 J/m2) or IL-1 alpha (10 ng/ml) independently induced small amount of TNF-alpha (< 25 pg/ml) from human dermal fibroblasts. However, combined treatments with UBV and IL-1 alpha induced 30-40-fold higher levels of TNF-alpha (750 pg/ml) than with either UVB of IL-1 alpha treatment alone. This synergy was also seen with mRNA expression. Maximum synergistic effect was observed when IL-1 alpha was added immediately after irradiation. Considering the fact that UVB is capable of causing release of IL-1 alpha from human keratinocytes and approximately 10% of incident UVB penetrates to the level of dermal fibroblasts, our results suggest that UVB may act in a cascade fashion to induce inflammation by initial release of keratinocyte IL-1 alpha, which then synergizes with UVB on hum...Continue Reading

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Citations

Jul 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Kiyotaka TanakaTakashi Okamoto
Oct 1, 2008·Archives of Dermatological Research·M M BashirV P Werth
Jun 3, 1999·The British Journal of Dermatology·M S DuthieM Norval
Feb 21, 2003·International Journal of Immunopathology and Pharmacology·S. KasaharaE. L. Cooper
May 12, 2001·The Journal of Investigative Dermatology·I M FreedbergM Blumenberg

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